The Effect of Bronchiectasis on the Exacerbation and Mortality in COPD

Completed

• Conditions: Bronchiectasis; Chronic Obstructive Pulmonary Disease
• Interventions: Other: No intervention

• Registration Number: NCT03950531
• Lead Sponsor: Ministry of Health, Turkey

Brief Summary

Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease of the airways and lungs that develops against harmful particles or gases with exacerbations. Coexistence of bronchiectasis with COPD may lead to worsening of the functional parameters as well as alteration of the microbiological pattern in exacerbations and may negatively affect the exacerbation result parameters.

Detailed Description

Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease of the airways and lungs that develops against harmful particles or gases with exacerbations. COPD exacerbations are characterized by worsening of dyspnea, coughing and expectoration. Exacerbations requiring hospitalization are the main cause of morbidity and mortality in COPD. Bronchiectasis is the irreversible extension of the bronchi. Usually follows with chronic sputum cough, airway obstruction and recurrent infection episodes. The association of bronchiectasis and COPD has long been known and its incidence is in the range of 30-50%. Coexistence of bronchiectasis with COPD may lead to worsening of the functional parameters as well as alteration of the microbiological pattern in exacerbations and may negatively affect the exacerbation result parameters.

Study Timeline

• Study Start: 2010-01-25
• Primary Completion: 2014-12-25
• Study Completion: 2017-01-25
• Status Verified: 2019-05
• Study First Submitted: 2019-05-13
• Study First Submitted QC: 2019-05-13
• Study First Posted: 2019-05-15
• Last Update Submitted: 2019-05-15
• Last Update Posted: 2019-05-17

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 122

Inclusion Criteria

• Patients who underwent thoracic tomography in the last year according to index exacerbation date were included in the study

Exclusion Criteria

• Cases that mimic COPD exacerbation (pneumonia, pulmonary thromboembolism, pulmonary congestion, pneumothorax, pleural effusion, lung malignancy, asthma, asthma-COPD overlap syndrome) and patients admitted to the intensive care unit were excluded from the study.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
COPD exacerbation with Bronchiectasis	No intervention	COPD patients who have been in exacerbation period and have bronchiectasis
COPD exacerbation without Bronchiectasis	No intervention	COPD patients who have been in exacerbation period and have no bronchiectasis

Primary Outcome Measures

Name	Time	Method
Charlson Comorbidity Index	1 hour	Comorbidity scores

Secondary Outcome Measures

Name	Time	Method
Spirometry	1 hour	Pulmonary function measurement