Mechanism Research of Traditional Chinese Medicine (the Comprehensive Treatment Regimen) in Treating Idiopathic Membranous Nephropathy by Genomewide Association Studies
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- Genome-wide single-nucleotide-polymorphism of IMN patients treated by the Comprehensive Treatment Regimen or conventional approach
研究概览
简要总结
The purpose of this study is to analysis the different genotype in the idiopathic membranous nephropathy patients which with different therapeutic outcomes after treated by the Comprehensive Treatment Regimen or immunosuppressive agents, and so as to looking for ideal markers to assess appropriate treatment approach and the long-term efficacy.
详细描述
The primary objective of this study is to looking for the gene level predictors in the patients who suffered from idiopathic membranous nephropathy. And according to the predictors, the clinicians could make a decision which method should be taken on IMN patients, Traditional Chinese Medicine or western medicine, and could get better results.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Clinical diagnosis of idiopathic membranous nephropathy
- •Chronic Kidney Disease (CKD)≤3 stage（Glomerular Filtration Rate (GFR)≥30ml/min）and 24 hour urinary protein≥3g
- •Voluntarily participated in the study and signed an informed consent
排除标准
- •Combined life-threatening complications such as serious infection
- •Abnormal glucose metabolism
- •Patients with malignant tumors or malignancy , HIV infection and a history of mental illness , acute central nervous system disease , serious gastrointestinal diseases,etc
- •Pregnancy or breast-feeding women
- •Undergoing other clinical trials
研究组 & 干预措施
CR/CTR group
The complete remission group treated by the Comprehensive Treatment Regimen
干预措施: The Comprehensive Treatment Regimen of Traditional Chinese Medicine (Drug)
NR/CTR group
The non-remission group treated by the Comprehensive Treatment Regimen
干预措施: The Comprehensive Treatment Regimen of Traditional Chinese Medicine (Drug)
CR/IA group
The complete remission group treated by Immunosuppressive Agents
干预措施: The immunosuppressive agents (Drug)
NR/IA group
The non-remission group treated by Immunosuppressive Agents.
干预措施: The immunosuppressive agents (Drug)
结局指标
主要结局
Genome-wide single-nucleotide-polymorphism of IMN patients treated by the Comprehensive Treatment Regimen or conventional approach
时间窗: one year
Screening for single-nucleotide-polymorphism as the prognostic factor for the TCM intervention of IMN patients.
次要结局
未报告次要终点