Circadian Modulation of Grape Consumption and Oxidative Stress Response
- Conditions
- Oxidative Stress
- Interventions
- Other: Grape
- Registration Number
- NCT05873530
- Lead Sponsor
- Idaho State University
- Brief Summary
This study investigated the effects of time-of-day of grape consumption on high-fat meal-induced oxidative stress.
- Detailed Description
Grape consumption acts on the immune system to produce antioxidant and anti-inflammatory effects. Since immune activity demonstrates circadian rhythmicity, with peak activity occurring during waking hours, the timing of grape intake may influence the magnitude of its antioxidant effect. This study followed a 2 x 2 factorial randomized, controlled design wherein healthy men and women (n = 32) consumed either a grape or placebo drink with a high-fat meal in the morning or evening. Urine was collected for measurements of biomarkers of oxidative stress and grape metabolites at baseline and post-meal at hour 1 and hours 1-6
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 32
- Healthy
- Age 18-50 y
- Employed in shift or night work
- Extreme early or late chronotype
- Presence of acute infection or chronic inflammatory disease
- Smoking
- Heavy aerobic exerciser
- Greater than moderate alcohol intake
- Pregnancy or lactation
- Use of non-steroidal anti-inflammatory medications or antioxidant dietary supplements.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Treatment Grape Grape or Placebo Time Grape Morning or evening
- Primary Outcome Measures
Name Time Method Urine F2-isoprostane hours 1-6 Oxidative stress marker
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Idaho State University
🇺🇸Pocatello, Idaho, United States