Vascular Risk Progression in Normal and Diabetes Control Subjects
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Diabetes
- Sponsor
- University of Nebraska
- Enrollment
- 90
- Locations
- 1
- Primary Endpoint
- Carotid intima media measurement change
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
The purpose of this study is to look at the progression of cardiovascular disease (CVD) in normal control individuals and in patients with controlled diabetes.
Detailed Description
Cardiovascular disease remains the greatest cause of mortality in people with diabetes mellitus. This observation study will evaluate non-traditional risk factors for their contributions to vascular disease progression as determined by carotid intima media thickness and history of vascular disease events over 1 year. This study requires annual checks of blood, urine, history, and carotid ultrasound for carotid intimal medical thickness.
Investigators
Eligibility Criteria
Inclusion Criteria
- •19 years old or more and willing to return for annual testing for 2 years.
- •Those with Diabetes need to have the condition for at least 5 years.
- •Normal controls need to have no diabetes, kidney disease, or chronic disease.
Exclusion Criteria
- •Estimated GFR \<60 (mL/min/1.73m2)
- •Any condition that would change weight dramatically in the near future such as malabsorption, pregnancy, malignancy
- •For Normal: BMI\>30, BP \> 140/90 , LDL \>
- •For Diabetes: BP\> 135/85, A1C\> 8%. LDL \> 100.
Outcomes
Primary Outcomes
Carotid intima media measurement change
Time Frame: 2 years
To describe carotid intima media measurement change over 2 year period in normal individuals compared to individuals with well controlled diabetes