Vascular Risk Progression in Normal and Diabetic Control Subjects.
- Conditions
- DiabetesInflammation
- Registration Number
- NCT00579228
- Lead Sponsor
- University of Nebraska
- Brief Summary
The purpose of this study is to look at the progression of cardiovascular disease (CVD) in normal control individuals and in patients with controlled diabetes.
- Detailed Description
Cardiovascular disease remains the greatest cause of mortality in people with diabetes mellitus. This observation study will evaluate non-traditional risk factors for their contributions to vascular disease progression as determined by carotid intima media thickness and history of vascular disease events over 1 year. This study requires annual checks of blood, urine, history, and carotid ultrasound for carotid intimal medical thickness.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 90
- 19 years old or more and willing to return for annual testing for 2 years.
- Those with Diabetes need to have the condition for at least 5 years.
- Normal controls need to have no diabetes, kidney disease, or chronic disease.
- Estimated GFR <60 (mL/min/1.73m2)
- Any condition that would change weight dramatically in the near future such as malabsorption, pregnancy, malignancy
- For Normal: BMI>30, BP > 140/90 , LDL > 130.
- For Diabetes: BP> 135/85, A1C> 8%. LDL > 100.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Carotid intima media measurement change 2 years To describe carotid intima media measurement change over 2 year period in normal individuals compared to individuals with well controlled diabetes
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
University of Nebraska Medical Center
🇺🇸Omaha, Nebraska, United States