Use of Point-of-Care Ultrasound (POCUS) for the Diagnosis of Acute Chest Syndrome in Patients With Sickle Cell Disease
Overview
- Phase
- Not Applicable
- Status
- Recruiting
- Sponsor
- Indiana University
- Enrollment
- 30
- Locations
- 1
- Primary Endpoint
- Participation rate
Overview
Brief Summary
Feasibility and reliability of ultrasound in the inpatient hematology setting.
Detailed Description
Acute chest syndrome (ACS) is a complication of sickle cell disease where individuals have symptoms of fever, low oxygen levels or difficulty breathing in the setting of a new lung finding on chest x-ray. Chest x-ray is a useful tool to identify it but has some side effects. The investigators think ultrasound will be an equally feasible, reliable tool and minimize some of the side effects associated with chest x-ray. Ultrasound is a non-invasive was to obtain an image that does not require radiation.
Study Design
- Study Type
- Interventional
- Allocation
- Na
- Intervention Model
- Single Group
- Primary Purpose
- Diagnostic
- Masking
- None
Eligibility Criteria
- Ages
- — to 25 Years (Child, Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Age: 0-25 years old
- •Diagnosis: Patients with a documented diagnosis of sickle cell disease (any genotype)
- •Disposition: Hospitalized for a SCD-related complication (e.g. VOC)
Exclusion Criteria
- •Patient is considered hemodynamically unstable to undergo consent and study procedures
- •Already has diagnosis of ACS prior to admission to inpatient unit
- •POCUS operator not available
Arms & Interventions
Ultrasound
Ultrasound days 1, 3, and 5 of hospitalization
Intervention: Point of Care Ultrasound (Device)
Outcomes
Primary Outcomes
Participation rate
Time Frame: Up to 5 days
Percentage of patients who are approached for study who agree to be on study
Retention rate
Time Frame: Up to 5 days
Percentage of patients who remain on study
Duration of exam
Time Frame: Up to 5 days
Time taken to complete POCUS examination
Acceptability of POCUS by the medical team (physicians and nursing)
Time Frame: Up to 5 days
Acceptability measured using a 5-point Likert Scale (Strongly Agree to Strongly Disagree) regarding use of POCUS in inpatient setting.
Secondary Outcomes
- Reliability of point of care ultrasound (POCUS) compared to standard of care (Chest X-ray)(Up to 5 days)
Investigators
Seethal Jacob, MD, MS
Associate Professor of Pediatrics
Indiana University