Comparison for Pethidine Requirement in Patients Received Spinal Morphine 0.2 and 0.3 mg for Post Lobectomy Analgesia
Phase 4
Completed
- Conditions
- Solitary MassLung Diseases
- Interventions
- Drug: spinal morphine 0.2 mgDrug: spinal morphine 0.3 mg
- Registration Number
- NCT01236495
- Lead Sponsor
- Mahidol University
- Brief Summary
The purpose of the study is to evaluate the amount of total pethidine requirement during the 48 hour postoperative period after receiving spinal morphine 0.2 and 0.3 mg.
- Detailed Description
Thoracotomy causes severe pain to the patients. Continuous thoracic epidural is a gold standard for postoperative pain. However, it needs skill. There are many alternatives such as spinal morphine, intercostal nerve block, cryoalangesia or interpleural block.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
- Age > 18 year and < 70 year
- Patient ASA physical status I-III.
- Scheduled for thoracotomy with lobectomy.
- Can operate a patient-controlled analgesia (PCA) device.
Exclusion Criteria
- Known hypersensitivity to morphine or pethidine
- History of bleeding tendency.
- Known case of infection at the back
- Patient refuse for spinal anesthesia
- History of cerebrovascular disease.
- Scheduled for video-assisted thoracoscopic lobectomy.
- Need mechanical ventilatory support during postoperative period
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description spinal morphine 0.2 mg spinal morphine 0.2 mg spinal morphine 0.2 mg spinal morphine 0.3 mg spinal morphine 0.3 mg spinal morphine 0.3 mg
- Primary Outcome Measures
Name Time Method pethidine requirement 48 hours Total pethidine requirement during 48 hours postoperative
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Faculty of Medicine, Siriraj Hospital
🇹ðŸ‡Bangkok, Thailand