The Impact of Serial Remote Ischemic Conditioning on Dynamic Cerebral Autoregulation in Healthy Adults
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 36
- Locations
- 1
- Primary Endpoint
- Dynamic Cerebral Autoregulation Parameter: Phase Difference(PD) in Degree
Study Overview
Brief Summary
The purpose of this study is to determine the impact of serial remote ischemic conditioning on dynamic cerebral autoregulation and related hematology indexes in healthy adults.
Detailed Description
Remote ischemic conditioning(RIC) is the phenomenon whereby brief cycles of ischemia and reperfusion, applied to a distant organ, provide protection to the target organ. Dynamic cerebral autoregulation(dCA), a mechanism to maintain the cerebral blood flow, has been proved to be critical for the occurrence,development and prognosis of ischemic neurovascular disease. In this study, we hypothesis that RIC provides neuro-protection by means of improving dCA.
Study Design
- Study Type
- Interventional
- Allocation
- Na
- Intervention Model
- Single Group
- Primary Purpose
- Treatment
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to 50 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •age from 18 to 50,both genders
- •willing to participate in follow-up visits
Exclusion Criteria
- •current or having a history of chronic physical diseases or mental diseases
- •suffering from infectious diseases in late one month
- •pregnant and lactating women#
- •smoking or drinking#
- •inability to cooperate sufficiently to complete the dCA examination
Outcomes
Primary Outcomes
Dynamic Cerebral Autoregulation Parameter: Phase Difference(PD) in Degree
Time Frame: 36 days
Dynamic cerebral autoregulation (dCA) is an important indicator of cerebrovascular function which related to the prognosis of cerebrovascular disease. DCA is usually calculated by transfer function analysis. Phase Difference (PD) is gengreated. Low PD at a low frequency band indicates impairment of autoregulation, as it suggests that cerebral blood flow velocity follows the changes in arterial blood pressure with a short delay.
Secondary Outcomes
- Dynamic Cerebral Autoregulation Parameter: Gain in cm/s/mmHg(36 days)