The Effect of Vitamin D on Fertility

Phase 4

Completed

• Conditions: Vitamin D3 Deficiency; Infertility; Infertility, Female; Vitamin D Deficiency
• Interventions: Drug: DEVIT-3

• Registration Number: NCT03890458
• Lead Sponsor: Akdeniz University

Brief Summary

Objective: To examine the effect of vitamin D supplements on the pregnancy and clinical pregnancy rate in embryo transfer cycles.

Design: Experimental study with a pre- and post-test. Setting: In Vitro Fertilization Center Patients: Its sample consisted of 118 women, 58 in the experimental group and 60 in the control group.

Intervention(s): At the beginning of the infertility treatment, the experimental group took vitamin D supplements, and the control group did not. Vitamin D supplementation for infertile women includes regulation of a diet rich in vitamin D, educational and motivational interviews about insolation, and taking vitamin D orally.

Main Outcome Measure(s): 25(OH)D and beta HCG levels

Detailed Description

Not available

Study Timeline

• Study Start: 2017-05-01
• Primary Completion: 2017-11-30
• Study Completion: 2017-11-30
• Status Verified: 2019-03
• Study First Submitted: 2019-03-11
• Study First Submitted QC: 2019-03-25
• Last Update Submitted: 2019-03-25
• Study First Posted: 2019-03-26
• Last Update Posted: 2019-03-26

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 118

Inclusion Criteria

• 18-45 years old
• literate in Turkish
• voluntary participation
• primarily infertile
• had undergone controlled ovarian hyperstimulation and had a fresh ET
• vitamin D levels lower than 30ng/mL before infertility treatment

Exclusion Criteria

• patients with uncorrected congenital or acquired uterine anomalies
• bone, parathyroid gland, kidney and liver disorders
• use of anticonvulsants/antacid drugs
• taking dietary supplements contain vitamin D
• secondary infertility

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Experimental	DEVIT-3	-

Primary Outcome Measures

Name	Time	Method
Blood Vitamin D level	The 25 (OH)D levels of the women were tested on the two weeks after embryo transfer. (Posttest)	The vitamin D blood test was measured by the level of 25(OH)D.

Secondary Outcome Measures

Name	Time	Method
Biochemical pregnancy	HCG levels of the women were evaluated on the two weeks after embryo transfer (Post test)	The pregnancy test was measured level of HCG in the blood.

Trial Locations

Locations (1)

Murat Özekinci; 🇹🇷 Antalya, Turkey