Exercise Training Improves Coronary Endothelial Dysfunction in Diabetes Mellitus Type 2 and Coronary Artery Disease

Phase 4

Completed

• Conditions: Coronary Artery Disease; Type 2 Diabetes Mellitus
• Interventions: Behavioral: Exercise training

• Registration Number: NCT00693537
• Lead Sponsor: Paracelsus Medical University

Brief Summary

Patients with type 2 diabetes mellitus suffer from accelerated coronary artery disease. We will assess the effects of exercise training on coronary endothelial function, vascular structure, and inflammation both in serum and skeletal muscle biopsies, as well as expression of diabetes candidate genes.

Detailed Description

Not available

Study Timeline

• Status Verified: 2008-06
• Study First Submitted: 2008-06-04
• Study First Submitted QC: 2008-06-06
• Study First Posted: 2008-06-09
• Last Update Submitted: 2019-08-29
• Last Update Posted: 2019-08-30

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

• written informed consent
• preserved left ventricular function (left ventricular ejection fraction ≥ 50%)
• a physical work capacity ≥ 50 W
• at least one significant coronary stenosis > 50%, whereas either the left anterior descending (LAD) or circumflex artery (RCX) has to be free from disease or stenoses ≤ 25% for the assessment of intracoronary flow measurements

Exclusion Criteria

• diseases further affecting endothelial function
• untreated hypertension (systolic blood pressure > 160 mm Hg or a diastolic blood pressure of > 90 mm Hg)
• cigarette smoking during the previous six months
• LDL-cholesterol > 4.3 mmol/l
• ventricular tachyarrhythmias
• chronic obstructive pulmonary disease
• severe renal or hepatic dysfunction
• valvular heart disease
• myocardial infarction within the previous 4 weeks

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
A	Exercise training	4 weeks in-hospital exercise training (6x15 min bicycle/day, 5 days/week) followed by a 5 months ambulatory exercise program (30 min ergometer/day, 5 days/week, plus 1h group exercise/week)

Trial Locations

Locations (1)

University Institute of Sports Medicine, Prevention and Rehabilitation; 🇦🇹 Salzburg, Austria