Transfer From Methadone to Buprenorphine Maintenance Treatment Using Buprenorphine Patches
Phase 4
- Conditions
- Heroin Addiction
- Registration Number
- NCT00750217
- Lead Sponsor
- Psychiatric University Hospital, Zurich
- Brief Summary
Buprenorphine is an important alternative to methadone in the maintenance treatment of heroin addiction. Transfer from methadone to buprenorphine requires a reduction of daily methadone dosage below 30 mg to avoid withdrawal after the first buprenorphine intake. The study hypothesis states that the transfer from a daily methadone dosage between 60 mg and 100 mg to buprenorphine can be carried out without withdrawal using buprenorphine patches (35 micro grams per hour) within 12 to 48 hours after last methadone intake.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 10
Inclusion Criteria
- Age between 18 and 60 years
- Methadone maintenance treatment for at least 3 months preceding the study
- Daily methadone dosage between 60mg amd 100mg
- Sufficient knowledge of German language
- Ability to give informed consent
Exclusion Criteria
- Daily methadone dosage below 60mg amd over 100mg
- Prescribed use of benzodiazepines over 30 mg equivalent to diazepam
- Misuse or dependence of alcohol and/or GHB/GBL
- Pregnant or breast-feeding women
- Known intolerance of buprenorphine
- Somatic diseases interfering with the study plan
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method Short Opiate Withdrawal Scale 14 days
- Secondary Outcome Measures
Name Time Method Heroin use 60 days
Trial Locations
- Locations (1)
Psychiatric University Hospital
🇨ðŸ‡Zurich, Switzerland