Prevalence of Keratoconus in Inflammatory Bowel Diseases

Not Applicable

Completed

• Conditions: Inflammatory Bowel Diseases; Keratoconus
• Interventions: Device: Opthalmologic measure with DM OPD scan III (Nidek)

• Registration Number: NCT02861339
• Lead Sponsor: Central Hospital, Nancy, France

Brief Summary

A retrospective study has shown the association between the inflammatory bowel diseases (IBD) and the presence of a keratoconus. This new study will measure the prevalence of keratoconus and follow its activity in patients affected by IBD and followed up in hepatology-gastroenterology department at Nancy Hospital. The prevalence of keratoconus will be compared to known data of literature about general population.

The secondary purpose is to search for a relationship between the presence of a keratoconus and activity criteria of IBD.

Perspectives are a systematic screening for keratoconus in patients affected by IBD with the amelioration of the ophthalmologic care of IBD patients and confirmation of the recent hypothesis of inflammatory origin of keratoconus.

Detailed Description

Not available

Study Timeline

• Study Start: 2014-02
• Primary Completion: 2014-07
• Study Completion: 2014-07
• Status Verified: 2016-08
• Study First Submitted: 2016-08-03
• Study First Submitted QC: 2016-08-05
• Last Update Submitted: 2016-08-05
• Study First Posted: 2016-08-10
• Last Update Posted: 2016-08-10

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 201

Inclusion Criteria

• Informed consent
• Affiliation to social security plan
• Diagnosis of IBD since more than 3 years, under treatment or not

Exclusion Criteria

• Protected person
• Pregnant or breastfeeding women
• Person in life-and-death emergency
• Person deprived of liberty
• Refusal to remove contact lenses, where necessary

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Keratoconus and IBD	Opthalmologic measure with DM OPD scan III (Nidek)	Opthalmologic measure with DM OPD scan III (Nidek)

Primary Outcome Measures

Name	Time	Method
Absence or presence of keratoconus in IBD patients	day 0	Data from OPD scan III corneal analyzer according to Rabinowitz and Klyce Maeda criteria. The presence of a keratoconus in at least one eye is considered positive.

Secondary Outcome Measures

Name	Time	Method
IBD clinical features using the Montreal classification for IBD	day 0