The Relationship Between Preoperative Serum Cytokine Level and Lenght of Stay in Hospital, Postoperative Pain Intensity, Functional Status, Joint Position Sense and X Ray Findings
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 29
- 试验地点
- 2
- 主要终点
- Pain intensty
研究概览
简要总结
Serum cytokines was assosiated with symptoms and progression of osteoartritis. It is unknown whether these cytokines have a predictive role on severity of symptoms after total knee arthroplasty (TKA) or not. The aim of this study is to investigate the relationships between the preoperative serum cytokine level (SCL) and lenght of stay in hospital, postoperative pain intensity, functional status, joint position sense and X ray.
Grade 4 osteoartritis degeneration who intern the hospital for total knee arthroplasty surgery. Serum Cytokine Levels (IL-6, TNFα, IL-1β) will be assessed before surgery. Pain intensity at rest/activity and valgite angle will be evaluated before surgery, postoperative 72 hour and postoperative 6 weeks. Functional status and joint position sense will be assessed before surgery and 6 weeks after surgery. Lenght of stay in hospital (LOS) will be recorded.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 45 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •aged between 45-75
- •were scheduled for unilateral or bilateral TKA
- •were diagnosed of OA with a severity Grade 4 according to the Kellgren-Lawrence (KL) classification.
排除标准
- •neuropathic pain
- •presurgery for same lower extremity
- •vascular disease
- •any chronic disease related to kidney, heart, liver
- •chronic inflammatory disease
结局指标
主要结局
Pain intensty
时间窗: pain intensity will be evaluated. It will determined pain intensity alteration from 2 weeks before surgery and at 72 hours and at 6 weeks following surgery
Rest and activity pain intensity will be evaluated by using 100 mm vertical line Visual Anolog Scale (VAS). Zero meet no pain, 10 unbearable pain
次要结局
- Functional Status(Functional status will be assessed before surgery and 6 weeks after surgery)
- X-Ray(X-ray evaluated before surgery, 72 hour after surgery and 6 weeks ater surgery)
- Joint Position Sense(It will be evaluated before surgery and 6 weeks after surgery)
- Serum Cytokine Level(Venous blood sample was collected 2 weeks before surgery)
研究者
Kübra Canli
Karadeniz Technical University
Karadeniz Technical University