Maternal Oxygen Administration for Fetal Distress II
- Conditions
- Oxygen Inhalation TherapyLabourFetal Distress
- Registration Number
- NCT03764696
- Lead Sponsor
- Navy General Hospital, Beijing
- Brief Summary
Supplementary oxygen is routinely administered to patients, even those with adequate oxygen saturations, in the belief that it increases oxygen delivery. However, oxygen delivery depends not just on arterial oxygen content but also on perfusion.
Maternal oxygen administration has been used in an attempt to lessen fetal distress by increasing the available oxygen from the mother. However, the effect of supplemental maternal oxygen therapy on fetal acid base status has been debated for more than seven decades.
The investigators found the use of 2 L/min maternal oxygen during the second stage of labor did not adversely affect either the umbilical artery pH value or the fetal heart rate (FHR) pattern distribution.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 140
at term (>37 weeks, <42 weeks), singleton, cephalic presentation, spontaneous or induced labor, normal labor, category I FHR tracings, 2 to 3 cm of cervical dilation in nulliparity, 1 to 2 cm of cervical dilation in multipara, informed consent.
respiratory or cardiovascular disease, diabetes mellitus or insulin-treated gestational diabetes mellitus, hypertension or preeclampsia, oligohydramnios, fetal growth restriction, placental abruption, cephalopelvic disproportion, meconium-stained amniotic fluid, tachysystole, having received O2, uterine incision (myomectomy or perforation), anemia, fever, chorioamnionitis, tobacco or alcohol use, disorders in oxygen saturations, hypotension, uncomfortable with facemask.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Cord arterial partial pressure of oxygen within 30 to 60 seconds of birth Immediately after delivery (within 30-60 seconds of birth), blood gas sample will be obtained.
Cord arterial pH values within 30 to 60 seconds of birth Immediately after delivery (within 30-60 seconds of birth), blood gas sample will be obtained.
Cord venous partial pressure of carbon dioxide within 30 to 60 seconds of birth Immediately after delivery (within 30-60 seconds of birth), blood gas sample will be obtained.
Cord venous pH values within 30 to 60 seconds of birth Immediately after delivery (within 30-60 seconds of birth), blood gas sample will be obtained.
Cord arterial partial pressure of carbon dioxide within 30 to 60 seconds of birth Immediately after delivery (within 30-60 seconds of birth), blood gas sample will be obtained.
Cord venous partial pressure of oxygen within 30 to 60 seconds of birth Immediately after delivery (within 30-60 seconds of birth), blood gas sample will be obtained.
- Secondary Outcome Measures
Name Time Method Rate of abnormal fetal heart tracing at 1 minute after birth
Related Research Topics
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Trial Locations
- Locations (3)
Department of Obstetrics and Gynecology, PLA Strategic Support Force Characteristic Medical Center
🇨🇳Beijing, China
Department of Obstetrics and Gynecology, Seventh Medical Center, Chinese PLA General Hospital
🇨🇳Beijing, China
Department of Obstetrics and Gynecology, Sixth Medical Center, Chinese PLA General Hospital
🇨🇳Beijing, China
Department of Obstetrics and Gynecology, PLA Strategic Support Force Characteristic Medical Center🇨🇳Beijing, China