A randomized controlled single blind trial of ketamine versus modified electroconvulsive therapy to improve neuropsychological and clinical outcomes in treatment resistant depression - EleKT

All India Institute of Medical Sciences New Delhi0 个研究点目标入组 0 人开始时间: 待定最近更新: 2023年6月26日

试验速览

暂无简介。

•1.Age 18-65 years
•2.Willing to give informed consent
•3.Ability to read Hindi or English language
•4.Fulfilling criteria of major depressive disorder as per Diagnostic and Statistical Manual 5 (DSM 5) in group 1 & 2
•5.Treatment resistance will be defined as the failure to respond to 2 adequate trials of different classes of antidepressant medications (Sackeim, 2001)
•6.Patients referred for MECT (for all study patients, a clinical decision to pursue neuromodulation would have already been made. Clinical treatment will be performed independently of this study).

•1.Patients with chronic neurological or other physical illness
•2.Suffering from any other psychiatric disorder other than major depressive disorder in their respective groups, as assessed by Mini International Neuropsychiatric Interview (MINI) screen
•3.Persistent mood disorders (dysthymia) and other and unspecified depressions based on DSM 5
•4.History of significant head trauma
•5.Patients with alcohol or other substance abuse (except nicotine and caffeine)
•6.Any history of seizure
•7.Previous history of receiving any surgical procedures or electrical or magnetic stimulation on brain
•8.Known or suspected pregnancy or lactating females

发起方

All India Institute of Medical Sciences New Delhi