RAndomized Clinical Trial in COvid19 Patients to Assess the Efficacy of the Transmembrane Protease Serine 2 (TMPRSS2) Inhibitor NAfamostat (RACONA Study)
Overview
- Phase
- Phase 2
- Intervention
- Nafamostat Mesilate
- Conditions
- COVID19
- Sponsor
- University Hospital Padova
- Enrollment
- 256
- Locations
- 1
- Primary Endpoint
- Time-to-clinical improvement
- Status
- Recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
RACONA is a prospective trial that will test the hypothesis that nafamostat can lower lung function deterioration and need for intensive care admission in COVID-19 patients.
Design: Adult hospitalized COVID-19 patients will be randomized in a prospective double-blind randomized placebo-controlled study to test the clinical efficacy of nafamostat mesylate (administered intravenously) on top of best standard of care.
Primary outcome measures: the time-to-clinical improvement, defined as the time from randomization to an improvement of two points (from the status at randomization) on a seven category ordinal scale or live discharge from the hospital, whichever comes first.
Detailed Description
Purpose: SARS-Cov-2 enters the lung cells by binding to ACE-2 and activating the protease TMPRSS2, which, therefore, can be a target for antiviral treatment. Accordingly, TMPRSS2 inhibitors prevent SARS-CoV cell entry in vitro. The most potent such inhibitors, nafamostat is being used as anticoagulant and anti-pancreatitis agent, and is approved for the treatment of cystic fibrosis as its mucolytic action can prevent lung function deterioration by owering airways infections. RACONA study will test the hypothesize that nafamostat is useful in COVID-19 lung involvement because COVID-19 entails activation of the coagulation cascade, pulmonary embolism, and bacterial superinfections.
Investigators
Gian Paolo Rossi, MD, FAHA, FACC
Prof.
University Hospital Padova
Eligibility Criteria
Inclusion Criteria
- •Hospitalized, COVID-19 positive, between 18 and ≤ 85 years of age;
- •Signed Inform Consent Form;
- •Body temperature \> 37.3 ℃;
- •Oxygenation criterion (any of the following): i) Oxygen saturation ≤94% on Room Air; ii) PaO2/FiO2 ratio ≤300 mmHg but \> 100 mmHg, if patient on supplemental oxygen; iii) SpO2/FiO2\<200 if no arterial blood gas available;
- •Respiratory rate (RR) ≥ 25 beats/min.
Exclusion Criteria
- •Pregnant or lactating females;
- •Unwillingness or inability to complete the study.
- •Rapidly deteriorating clinical condition or low likelihood to complete the study according to the investigator;
- •eGFR \< 30 ml/min/m2 assessed with CKD EPI formula;
- •Current or chronic history of liver disease (Child Pugh score ≥ 10), or known hepatic or biliary abnormalities;
- •Participation in a clinical trial with an investigational product within the following time period prior to the first dosing day in the current study: 5 half-lives or twice the duration of the biological effect of the investigational product (whichever is longer);
- •Patients requiring high doses of loop diuretics (i.e. \> 240 mg furosemide daily) with significant intravascular volume depletion, as assessed clinically;
- •History of allergy;
- •History of sensitivity to heparin or heparin-induced thrombocytopenia;
- •Unstable hemodynamics in the preceding 4 hours (SBP \< 90 mmHg, and/or vasoactive agents required);
Arms & Interventions
Nafamostat
Nafamostat mesylate on top of best standard of care.
Intervention: Nafamostat Mesilate
Placebo
Placebo on top of best standard of care.
Intervention: Placebo
Outcomes
Primary Outcomes
Time-to-clinical improvement
Time Frame: day 1 until day 28
Time-to-clinical improvement (time from randomization to an improvement of two points (from the status at randomization) on a 7 category ordinal scale or live discharge from the hospital, whichever came first.
Secondary Outcomes
- pO2/FiO2 ratio(day 1 until day 28)
- Critical or dead patients(day 1 until day 28)
- Responders(day 1 until day 28)
- Hospitalization(day 1 until day 28)
- Mechanical ventilation duration(day 1 until day 28)
- Cardiovascular disease(day 1 until day 28)
- SOFA score over time(day 1 until day 28)
- Mechanical ventilation(day 1 until day 28)