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临床试验/NCT06588777
NCT06588777招募中不适用

Ultrasound Guided Modified Thoracoabdominal Nerve Block Through Perichondrial Approach (M-TAPA) Versus Quadratus Lumborum Block for Postoperative Analgesia in Laparoscopic Cholecystectomy

Ain Shams University1 个研究点 分布在 1 个国家目标入组 52 人开始时间: 2024年9月1日最近更新:
适应症
干预措施

试验速览

阶段
不适用
状态
招募中
入组人数
52
试验地点
1
主要终点
Time to first Rescue Analgesia

研究概览

简要总结

This study aims to compare the efficacy of using Ultrasound guided modified thoracoabdominal nerve block through perichondrial approach (M-TAPA) versus quadratus lumborum block for postoperative analgesia in laparoscopic cholecystectomy under general anesthesia.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Prevention
盲法
Single (Participant)

入排标准

年龄范围
21 Years 至 71 Years(Adult, Older Adult)
性别
All
接受健康志愿者
否

入选标准

  • •Adult patients aging ≥ 21 years to ≤ 70 of both sexes.
  • •Patients undergoing Laparoscopic cholecystectomy surgeries.
  • •ASA physical status classes I - II.

排除标准

  • •Patient's refusal of procedure or participation in the study.
  • •ASA classes III or above.
  • •Coagulopathy and bleeding disorders.
  • •Evidence of Local skin infections at site of injection.
  • •Body mass index >40kg/m2
  • •A history of relevant local anesthetic allergy.

研究组 & 干预措施

Modified thoracoabdominal nerve block through perichondrial approach (M-TAPA)

Experimental

Using the in plane technique A deep angle was given to the costochondral angle at the edge of the 10th costal margin with the probe in the sagittal direction to view the lower surface of the costal cartilage in the midline. A 22-G, 100-mm block needle will be inserted in the cranial direction using the in-plane technique and the needle tip will be moved to the posterior aspect of the 10th costal cartilage. It is noted that the needle tip never crossed the cranial edge of the 10th costal cartilage and 20 mL of 0.25% bupivacaine will be injected into the lower surface of the chondrium to make Modified thoracoabdominal nerve block through perichondrial approach (M-TAPA).

干预措施: Modified thoracoabdominal nerve block through perichondrial approach (M-TAPA) (Procedure)

Quadratus lumborum block

Experimental

Using the in plane technique the probe will be placed in the mid-axillary line between the lower costal margin and the iliac crest in a transverse plane to view all abdominal layers. The probe will be moved towards the posterior axillary line, to reach a point where all three abdominal muscle layers merge to form aponeurosis.

The aponeurosis will then be followed dorsally until the quadratus lumborum muscle is seen deep to transversalis fascia with its attachment to the transverse process of the L4 vertebral body. A 22 G, 100 mm, blunt, insulated nerve block needle will be inserted 1 cm medial to the probe and advanced using the in-plane technique with ultrasound real-time assessment. The injection site will be the junction of transversalis fascia and the anterolateral border of quadratus lumborum muscle.

干预措施: Quadratus lumborum block (Procedure)

结局指标

主要结局

Time to first Rescue Analgesia

时间窗: 24 hours postoperative

Is to measure the first time to resque analgesia postoperative (24 hours)

次要结局

  • The total requirements of rescue analgesia Meperidine (pethidine) over the first 24 hours postoperative(24 hours postoperative)
  • Heart rate(at intervals of 0 (PACU), 1, 2, 4, 6, 12, 18 and 24 hours postoperatively)
  • Blood pressure(at intervals of 0 (PACU), 1, 2, 4, 6, 12, 18 and 24 hours postoperatively)
  • Spo2 measuring(at intervals of 0 (PACU), 1, 2, 4, 6, 12, 18 and 24 hours postoperatively)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Ahmed Hassan Helmy

Clinical Doctor

Ain Shams University

研究点 (1)

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