Prevalence and Factors of Sarcopenia in Patients With Primary Sjogren's Syndrome
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Sarcopenia
- Sponsor
- Acibadem University
- Enrollment
- 50
- Locations
- 1
- Primary Endpoint
- Grip Strength
- Status
- Completed
- Last Updated
- 3 years ago
Overview
Brief Summary
Sarcopenia is a progressive condition characterized by decline in muscle strength and muscle mass. Although the mechanism of sarcopenia has not been fully elucidated, it may be caused by protein-poor diet, vitamin D deficiency, hormonal changes, increase in inflammatory cytokine level and oxidative stress. For this reason, it is thought that determining the prevalence of sarcopenia in rheumatological diseases with chronic inflammation and protecting patients from possible comorbidities with appropriate interventions may be an important factor in maintaining and improving the functional levels and quality of life of patients.
The aim of our study was to investigate the prevalence and its associated factors of sarcopenia in individuals with primary Sjögren's Syndrome.
Investigators
Özgül Öztürk
Assistant Professor
Acibadem University
Eligibility Criteria
Inclusion Criteria
- •Diagnosed with primary Sjogren's syndrome by an experienced rheumatologist according to European League Against Rheumatism (EULAR) ve American College of Rheumatology (ACR) criteria
- •Being 40 years or older.
Exclusion Criteria
- •Pregnancy,
- •Malignancy,
- •Presence of other rheumatological diseases,
- •Presence of diabetes mellitus
- •Presence of neurological problems
- •Presence of osteoarthritis
Outcomes
Primary Outcomes
Grip Strength
Time Frame: 1 day
Grip strength will be evaluated with JAMAR dynamometer. The patient is positioned in a chair with the elbow flexed to 90 degrees and the wrist in a neutral position, and he/she is asked to grip as strong as he/she can do for 3 seconds. The test is repeated 3 times and the highest value is recorded.
Gait Speed
Time Frame: 1 day
The patient will be asked to walk 4-meters for two times. The shortest time to walk through this distance will be recorded.
5 Times Sit to Stand Test
Time Frame: 1 day
This test includes the calculation of the time it takes to sit and get up from the chair 5 times while the arms are crossed over the shoulders.
Muscle Mass
Time Frame: 1 day
Muscle mass will be calculated via bioimpedance analysis method. Fat Free Mass will be recorded using TANITA BC 532 Bioimpedance Device and Skeletal Muscle Mass and Skeletal Muscle Mass will be calculated.
Secondary Outcomes
- EULAR Sjogren's Syndrome Patient Reported Index (ESSPRI)(1 day)
- EULAR Sjogren's Syndrome Disease Activity Index (ESSDAI)(1 day)
- Malnutrition Evaluation(1 day)