Evaluation and Comparison of Semaphorin 4D (SEMA4D) Levelsin gingival crevicular fluid (GCF) of periodontally healthy, diseasedsubjects and it’s response to treatment : A Clinico-BiochemicalInterventional Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- chronic periodontitis patients.
研究概览
简要总结
This is a clinico biochemical interventional study to compare the GCF SEM4D levels in periodontally healthy, patients with chronic periodontitis and its response to scaling and root planing.
Study design:
Group I (Periodontally healthy) consisting of 25 subjects with clinically healthy periodontium and no evidence of disease (GI equal to 0, PPD equal to or less than 3 mm, CAL equal to 0)
Group II (Chronic periodontitis) consisting of 25 subjects with chronic periodontitis (GI greater than 1, PPD greater than 3 mm, CAL greater than 1mm)
GCF samples will be collected from all subjects to evaluate the GCF SEMA4D levels.
The subjects of group II will undergo scaling and root planing and will be re-evaluated after 4 weeks to re-determine the SEMA4D levels. The data will be entered into Microsoft excel sheet and will be further analyzed with the help of SPSS software.
研究设计
- 研究类型
- Interventional
- 分配方式
- Not Applicable
- 盲法
- Not Applicable
入排标准
- 年龄范围
- 30.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •1.Subjects between the age group of 30 – 60 years.
- •2.Subjects who have not received periodontal therapy, within preceding six months.
- •3.Subjects who readily give informed consent for the study.
- •4.Systemically healthy patients .
排除标准
- •1.Consumption of tobacco in any form and alcoholics.
- •2.Pregnant and lactating females.
- •Subjects who have received anti-inflammatory, antibiotic and steroid drugs in previous three months.
结局指标
主要结局
chronic periodontitis patients.
时间窗: Baseline | 4 weeks after scaling and root planing
3.To compare the levels of GCF SEMA4D in
时间窗: Baseline | 4 weeks after scaling and root planing
4.To correlate the effect of scaling and root
时间窗: Baseline | 4 weeks after scaling and root planing
1.To determine the level of GCF SEMA4D in
时间窗: Baseline | 4 weeks after scaling and root planing
2.To determine the level of GCF SEMA4D in
时间窗: Baseline | 4 weeks after scaling and root planing
patients.
时间窗: Baseline | 4 weeks after scaling and root planing
periodontally healthy patients.
时间窗: Baseline | 4 weeks after scaling and root planing
periodontally healthy and chronic periodontitis
时间窗: Baseline | 4 weeks after scaling and root planing
planing on the level of GCF SEMA4D in
时间窗: Baseline | 4 weeks after scaling and root planing
patients with chronic periodontitis.
时间窗: Baseline | 4 weeks after scaling and root planing
次要结局
- To evaluate improvement in plaque index(,gingival index,pocket probing depth and clinical)