Reducing Perioperative S. Aureus Transmission Via OR PathTrac

Completed

• Conditions: S. Aureus Transmission; Surgical Site Infection
• Interventions: Other: OR PathTrac Feedback Optimization

• Registration Number: NCT04657185
• Lead Sponsor: Georgetown University

Brief Summary

Healthcare-associated infections (HAIs) occur frequently and are associated with patient harm. It is important that healthcare facilities take the necessary steps to prevent the spread of resistant bacteria. ESKAPE bacteria (Enterococcus, S. aureus, Klebsiella, Acinetobacter, Pseudomonas, and Enterobacter spp.) are particularly pathogenic. Isolation of these pathogens from intraoperative reservoirs has been associated with postoperative infection development (i.e. surgical site infections). This project involves implementation of a software platform and bacterial collection system (OR PathTrac) that leverages the epidemiology of intraoperative bacterial transmission to guide dynamic, prospective improvements in perioperative infection control measures. We will assess the effectiveness of OR PathTrac feedback in optimizing an evidence-based, multifaceted, perioperative infection control program.

Detailed Description

Our objective was to analyze the impact of surveillance feedback optimization of a multifaceted, perioperative infection control program on S. aureus transmission and SSIs. A multifaceted infection control program was implemented over 8 months (November 2018 to June 2019). A prospective cohort impact study was then conducted over 8 months (July 2019 to March 2020) to compare the incidence of within-case S. aureus transmission (primary outcome) and surgical site infection (secondary outcome) before (4.5 months) and after (3.5 months) implementation of surveillance feedback.

Study Timeline

• Study Start: 2019-07-15
• Primary Completion: 2020-03-20
• Study Completion: 2020-03-20
• Status Verified: 2020-12
• Study First Submitted: 2020-12-01
• Study First Submitted QC: 2020-12-01
• Last Update Submitted: 2020-12-01
• Study First Posted: 2020-12-08
• Last Update Posted: 2020-12-08

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 804

Inclusion Criteria

• Adult patients requiring anesthesia and intravenous catheter placement.

Exclusion Criteria

• Pediatric patients, without requirement of anesthesia and/or intravenous catheter placement.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
After OR PathTrac Feedback	OR PathTrac Feedback Optimization	Patients undergoing surgery with an evidence-based, multifaceted, perioperative infection control program in place AND OR PathTrac feedback optimization.

Primary Outcome Measures

Name	Time	Method
within-case S. aureus transmission	From patient entry into the operating room until case end, up to 6 hours	S. aureus transmission events detected within a surgical case

Secondary Outcome Measures

Name	Time	Method
surgical site infection	Up to 90 days following surgery	evidence of infection (office note documentation with anti-infective order and/or isolation of one or more potentially pathogenic organisms

Trial Locations

Locations (1)

Georgetown University; 🇺🇸 Georgetown, District of Columbia, United States