Predictors of Postoperative Atrial Fibrillation After CABG

Active, not recruiting

• Conditions: Coronary Artery Disease; Atrial Fibrillation New Onset
• Interventions: Procedure: CABG

• Registration Number: NCT05888168
• Lead Sponsor: Kun Hua

Brief Summary

This observational study aims to identify the determinants or predictors of postoperative atrial fibrillation (POAF) in patients who have undergone coronary artery bypass grafting (CABG). The study will compare two cohorts: patients who developed POAF and those who did not (non-POAF), with the aim of improving postoperative care, reducing complications, and refining patient risk stratification.

Detailed Description

Demographics (age, sex, ethnicity), lifestyle factors (smoking, alcohol, physical activity), and medical history (diabetes, hypertension, prior heart diseases) will be recorded. Surgical procedure details (number of grafts, use of intraoperative devices), anesthesia, and medications administered. Levels of inflammatory markers, cardiac-specific markers, and other relevant biomarkers at baseline and postoperatively. Other complications besides POAF, hospital length of stay, ICU admission, readmission rate, and mortality will also be monitored.

Study Timeline

• Study Start: 2018-01-01
• Study First Submitted: 2023-05-21
• Status Verified: 2023-06
• Study First Submitted QC: 2023-06-01
• Last Update Submitted: 2023-06-01
• Study First Posted: 2023-06-05
• Last Update Posted: 2023-06-05
• Primary Completion: 2023-12-15
• Study Completion: 2024-05-01

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 15000

Inclusion Criteria

• Adults aged 18 years or older.
• Patients who underwent CABG.

Exclusion Criteria

• Patients with a history of preoperative atrial fibrillation or other significant arrhythmias.
• Patients who underwent other concurrent cardiac procedures (e.g., valve surgery) in addition to CABG.
• Patients who cannot provide informed consent or lack adequate follow-up information.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
POAF	CABG	This group will consist of patients who have developed postoperative atrillary fibrillation (POAF) after undergoing coronary artery bypass grafting (CABG).
Non-POAF	CABG	This group will consist of patients who have not developed postoperative atrillary fibrillation (POAF) after undergoing coronary artery bypass grafting (CABG).

Primary Outcome Measures

Name	Time	Method
Incidence of POAF	During hospital stay, up to 30 days	This will be determined based on electrocardiograms (ECG) and/or relevant medical records, within 30 days post-CABG.

Secondary Outcome Measures

Name	Time	Method
Hospital length of stay	During hospital stay, up to 30 days
ICU admission time	During hospital stay, up to 30 days
Number of participants with Stroke	During hospital stay, up to 30 days
Mortality	During hospital stay, up to 30 days

Trial Locations

Locations (1)

Beijing Anzhen Hospital; 🇨🇳 Beijing, China