Development of a New Neuroimaging Method Aimed to Differentiate Mnesic Abilities of Alzheimer and Depressed Patients

Centre Hospitalier Universitaire de Besancon1 site in 1 country30 target enrollmentFebruary 20, 2015

ConditionsAlzheimer Disease Depression

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Alzheimer Disease
Sponsor: Centre Hospitalier Universitaire de Besancon
Enrollment: 30
Locations: 1
Primary Endpoint: Amplitude of event-related potentials
Last Updated: 8 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

The purpose of this study is to use a new method to differentiate mnesic abilities of early alzheimer patients and patients with a depressive disorder.

This method is based on the recording of cerebral activity while patients listen to familiar, unfamiliar and newly-learned music.

Registry

clinicaltrials.gov

Start Date

February 20, 2015

End Date

August 20, 2018

Last Updated

8 years ago

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

Centre Hospitalier Universitaire de Besancon

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•Being right-handed
•recorded consent
•For Alzheimer patients: Mini Mental Status Examination (MMSE) score \>= 18
•For patients with a depressive disorder : Major Depressive Disorder according to Diagnostic and Statistical Manual of Mental Disorders (DSM IV) and Montgomery-Asberg depression rating scale (MADRS) score \>= 25
•For healthy controls : no cognitive deficit, MADRS score \< 25, no depressive disorder according to DSM IV

Exclusion Criteria

•Auditory deficit
•contraindication to a high-density electroencephalography exam
•refusal to participate in the study

Outcomes

Primary Outcomes

Amplitude of event-related potentials

Time Frame: day 1 for familiar and unfamiliar songs and day 14 for newly learned songs

Measurements of the amplitude of event-related potentials with electroencephalography at day one for familiar and unfamiliar songs and after 2 weeks for newly learned songs