Development of a New Neuroimaging Method Aimed to Differentiate Mnesic Abilities of Alzheimer and Depressed Patients
试验速览
- 阶段
- 不适用
- 入组人数
- 30
- 试验地点
- 2
- 主要终点
- Amplitude of event-related potentials
研究概览
简要总结
The purpose of this study is to use a new method to differentiate mnesic abilities of early alzheimer patients and patients with a depressive disorder.
This method is based on the recording of cerebral activity while patients listen to familiar, unfamiliar and newly-learned music.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 60 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Being right-handed
- •recorded consent
- •For Alzheimer patients: Mini Mental Status Examination (MMSE) score >= 18
- •For patients with a depressive disorder : Major Depressive Disorder according to Diagnostic and Statistical Manual of Mental Disorders (DSM IV) and Montgomery-Asberg depression rating scale (MADRS) score >= 25
- •For healthy controls : no cognitive deficit, MADRS score < 25, no depressive disorder according to DSM IV
排除标准
- •Auditory deficit
- •contraindication to a high-density electroencephalography exam
- •refusal to participate in the study
研究组 & 干预措施
Alzheimer patients
Cerebral measurements from high-density electroencephalography are recorded in Alzheimer patients. The same protocol is applied in the 3 arms
干预措施: high-density electroencephalography (Device)
patients with a depressive disorder
Cerebral measurements from high-density electroencephalography are recorded in patients with a depressive disorder. The same protocol is applied in the 3 arms
干预措施: high-density electroencephalography (Device)
Healthy controls
Cerebral measurements from high-density electroencephalography are recorded in healthy controls
干预措施: high-density electroencephalography (Device)
结局指标
主要结局
Amplitude of event-related potentials
时间窗: day 1 for familiar and unfamiliar songs and day 14 for newly learned songs
Measurements of the amplitude of event-related potentials with electroencephalography at day one for familiar and unfamiliar songs and after 2 weeks for newly learned songs
次要结局
- Spectral power(day 1 for familiar and unfamiliar songs and day 14 for newly learned songs)