Biochemical Evaluation of the Effect of Orthodontic Treatment with Aligner on Periodontal Parameters and OPG and RANKL Salivary Values
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 25
- 试验地点
- 2
- 主要终点
- The total amount of OPG in saliva
研究概览
简要总结
The aim of this study was to determine the effect of orthodontic treatment with aligner on changes in osteoprotegerin (OPG) and receptor activator of NF-κB ligand (RANKL) levels in saliva samples and to investigate the possible relationship between periodontal clinical parameters. Materials and Methods: A total of 25 (n=25) saliva samples were taken from systemically healthy non-smoking individuals who were planned to receive orthodontic treatment with aligner before treatment. Whole mouth clinical periodontal measurements including probing depth (PD), clinical attachment level (CAL), bleeding on probing (BOP), gingival index (GI) and plaque index (PI) were also recorded and repeated at 1 and 3 months. Enzyme-linked immunosorbent assay (ELISA) was used to determine OPG and RANKL levels in biological samples.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 30 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Systemically healthy (The determination of healthy volunteers will be based on the statements of the patients in the anamnesis. No additional examinations will be made.)
- •Must receive orthodontic treatment with aligners and must have accepted the treatment
- •Non-smoker
- •No medication for continuous use
- •Those who have not used antibiotics, anti-inflammatory and systemic corticosteroid drugs in the last 6 months.
- •Not in pregnancy or lactation period.
排除标准
- •Any oral or systemic disease
- •Regularly using a systemic medication
- •During pregnancy or lactation
- •Received periodontal treatment within the last 6 months.
- •Those who received antibiotic, anti-inflammatory or systemic corticosteroid medication in the last 6 months
- •Smokers are not included in the study
结局指标
主要结局
The total amount of OPG in saliva
时间窗: 24 hours after taking the clinical measurements
The total amount of osteoprotegerin in saliva
次要结局
- The total amount of RANKL in saliva(24 hours after taking the clinical measurements)
研究者
Burçin Akan
Doç. Dr.
Izmir Katip Celebi University