Effect of 4-session Metacognitive Training in Chinese Adult Outpatients With Schizophrenia Spectrum Disorders and Major Depressive Disorder

Not Applicable

Completed

• Conditions: Depression; Delusions
• Interventions: Other: Metacognitive Training

• Registration Number: NCT03449394
• Lead Sponsor: Chinese University of Hong Kong

Brief Summary

Psychological studies have shown that individuals tend to attribute causes of positive and negative events differently. Specifically, individuals hold an internalising or externalising bias of attribution which, in the case of particular patient groups, was found to polarize to the extreme. Such extreme attributional styles have found to have a direct impact on emotions, leading to a waning course of psychiatric disorders. This project aims to further examine the theoretical links between attributions and emotions using a transdiagnostic approach, and the effect of a 4-session process-based intervention on attributional biases.

Detailed Description

Not available

Study Timeline

• Study Start: 2015-04
• Study First Submitted: 2018-01-23
• Study First Submitted QC: 2018-02-22
• Study First Posted: 2018-02-28
• Primary Completion: 2019-11
• Study Completion: 2019-11
• Status Verified: 2020-01
• Last Update Submitted: 2020-01-22
• Last Update Posted: 2020-01-23

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 113

Inclusion Criteria

• Aged 18-65 years
• Clinical diagnosis of non-organic psychosis or major depressive disorder
• Presentation of delusions/a moderate level of depression

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Exclusion Criteria

• Clinical diagnosis of psychotic depression or depression with psychotic features
• Primary diagnosis of substance misuse or learning disability
• Participation of any cognitive/reasoning training program

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Depression (Tx)	Metacognitive Training	-
Delusions (Tx)	Metacognitive Training	-

Primary Outcome Measures

Name	Time	Method
Attributional style as measured by the Internal, Personal and Situational Attributions Questionnaire (IPSAQ)	6 months	IPSAQ consists of hypothetical scenarios. Participants are required to think of a single, most likely causal explanation to each of the hypothesized situations, and then to categorize this cause as being internal, external-personal or external-situational.
Depressive symptomatology as measured by Beck Depression Inventory - II (BDI-II) and Calgary Depression Scale (CDS)	6 months	Beck Depression Inventory - II (BDI-II) is a 21-item self-report inventory that assesses symptoms of depression. Scores can range from 0 to 63, with higher scores reflecting greater symptom severity. Calgary Depression Scale (CDS) is a nine-item structured interview scale that assesses depressive symptoms in patients with schizophrenia.
Conviction of beliefs as measured by the Psychotic Symptom Rating Scale (PSYRATS)	6 months	The Psychotic Symptom Rating Scale (PSYRATS) is a 17-item semi-structured interview measuring the severity of multiple dimensions of auditory hallucinations and delusions, including conviction and duration.
Belief flexibility as measured by Maudsley Assessment of Delusions Schedule (MADS) and the BADE task	6 months	Maudsley Assessment of Delusions Schedule (MADS) is a standardised interview assessment that records whether participants could consider possibility of being mistaken (PM) about their delusional experience, any possible alternative explanations for the experience (EoE), and their reaction to hypothetical contradiction (RTHC). BADE task is an experimental design for measuring participants' bias against disconfirmatory evidence.
Psychotic symptomatology as measured by Positive and Negative Syndrome Scale (PANSS)	6 months	Positive and Negative Syndrome Scale (PANSS) is an interview-based assessment of the severity of symptoms associated with schizophrenia, including positive, negative, and general psychopathology.
State-trait personality as measured by the State-Trait Personality Inventory (STPI)	6 months	State-Trait Personality Inventory (STPI) consists of 8 self-report scales, each containing 10 items covering state and trait anger, anxiety, curiosity and depression.

Secondary Outcome Measures

Name	Time	Method
Severity of generalized anxiety disorder as measured by Generalised Anxiety Disorder 7 (GAD-7)	6 months	Generalised Anxiety Disorder 7 (GAD-7) is a self-reported questionnaire for screening and assessing severity of generalised anxiety disorder (GAD). This scale consists of seven items that measure severity of various signs of GAD according to reported response categories.
Cognitive capacity as measured by the Chinese version of the Wechsler Adult Intelligence Scale - III (WAIS-III)	Baseline	Three subtest short form - vocabulary, matrix reasoning and information - will be administered at baseline to assess the participants' cognitive capacity.

Trial Locations

Locations (1)

Chinese University of Hong Kong; 🇭🇰 Hong Kong, Hong Kong