Prospective Observational study of Effectiveness and tolerability of Olanzapine Long-Acting Injection in patients with Schizophrenia

This is a prospective observational study, and the study aims to evaluate the safety and efficacy of olanzapine long-acting injection in treatment nonadherent patients with schizophrenia. . The diagnosis and the drug to be prescribed will be decided by the consultant psychiatrist. Patients who are prescribed olanzapine long-acting injection by a consultant psychiatrist will be included in the study. A total of 50 patients who meet the inclusion criteria and who will provide written informed consent will be recruited for the study. LAI of olanzapine is administered in the upper and outer quadrant of the gluteal muscle using the Z-track technique, and after that, patients will be kept under observation for 3 hours for post-injection delirium and sedation syndrome. Assessment of participants will be done at every follow up by trained resident doctor of psychiatry department during each follow-up using semi structured proforma, it includes demographic details, positive and negative syndrome scale (PANSS) and Clinical global impression on severity and improvement (CGI) for efficacy, simpson-agnus score (SAS), Barnes akathisia scale (BAS), Abnormal involuntary movement scale (AIMS), Richmond agitation sedation scale (RASS) for safety. Assessment of laboratory investigation reports will be done at screening period and then every three months till 12 months.