Blood Pressure and Central Vascular Stiffness in Obese Children. Relationship to Metabolic Disturbances and Subclinical Cardiovascular Damage. Effect of Weight Reduction
试验速览
- 阶段
- 不适用
- 入组人数
- 100
- 试验地点
- 4
- 主要终点
- Central Blood Pressure
研究概览
简要总结
The global epidemic of obesity in childhood continues to evolve and threaten future health and life expectancy primarily due to the increased incidence of cardiovascular disease. Obesity is strongly related to high blood pressure (hypertension) and both conditions pose a risk for target organ damage, which can follow a subject from childhood into adult life. The AORTA study will investigate central hemodynamics and organ damage in 100 obese children and adolescents in order to gain insight to the complex interplay of hypertension, obesity and subclinical damage in order to intensify more precise prevention, thereby reducing the future development of cardiovascular disease.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 10 Years 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •age 10-18
- •BMI for age and sex above 95 percentile
- •referred for treatment at the The Children's Obesity Clinic, Department of Paediatrics, Holbaek Hospital, University of Copenhagen
- •oral and written consent by their parents
排除标准
- •children who can not cooperate to DEXA scanning or other procedures
- •linguistic difficulties that impair communication
结局指标
主要结局
Central Blood Pressure
时间窗: one year follow up
Obtained by the SphygmoCor Device, software version 9, AtCor Medical, Australia.
次要结局
- Pulse Wave velocity(one year follow up)
- Ambulatory Blood Pressure Monitoring and Clinic Blood Pressure(one year follow up)
- Heart Rate variability(one year follow up)
- Urine Albumine-Creatinine Ratio (UACR)(one year follow up)
- Echocardiography and ultrasound of aortic wall distensibility(one year follow up)
- Metabolic and Cardiovascular Blood Samples(one year follow up)
- Electrocardiography(one year follow up)
- Dual energy X-ray absorptionmetry (DEXA scan)(one year follow up)
- Anthropometric measures(one year follow up)