The effect of a structured exercise program on oxidative capacity and mitochondrial (dys)function in type 2 diabetes

Completed

• Conditions: Type 2 diabetes; Non-insulin-dependent diabetes mellitus; Nutritional, Metabolic, Endocrine

• Registration Number: ISRCTN23677189
• Lead Sponsor: niversity Maastricht (UM) (Netherlands)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2010-03-16
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: Male
• Target Recruitment: 36

Inclusion Criteria

Group A: long-term type 2 diabetes group (intervention group):
1. Male
2. Diagnosed with type 2 diabetes greater than 5 years according to World Health Organization (WHO) criteria
3. Exogenous insulin use greater than 2 years
4. Clinical signs of diabetic polyneuropathy and/or other diabetes-related
5. Aged 45 - 70 years
6. Body mass index (BMI) 26 - 42 kg/m^2
7. Sedentary behaviour
8. Agreement to volunteer for the study by giving a written informed consent

Group B: intermediate hyperglycaemia group/early-diagnosed type 2 diabetes patients:
1. Male
2. Intermediate hyperglycemia according to WHO criteria
3. HbA1c less than or equal to 6.0%
4. Aged 45 - 70 years (matched with group A)
5. BMI 26 - 42 kg/m^2 (matched with group A)
6. Wmax (cycle ergometer): 100 - 220 Watt
7. Sedentary behaviour
8. Agreement to volunteer for the study by giving a written informed consent

Group C: overweight/obese but otherwise healthy subjects with normal glucose tolerance:
1. Male
2. Normal glucose tolerance according to WHO criteria
3. HbA1c less than or equal to 6.0%
4. Aged 45 - 70 years
5. BMI 26 - 42 kg/m^2 (matched with group A)
6. Wmax: 100 - 220 Watt
7. Sedentary behaviour
8. Agreement to volunteer for the study by giving a written informed consent

Exclusion Criteria

Group A:
1. Unable to participate in a structured exercise intervention for 12 months
2. Use of thiazolidinions
3. Use of beta-blocker therapy less than 6 months

Group B and C:
1. Family history of type 2 diabetes
2. Use of beta-blocker therapy
3. History/clinical signs of cardiovascular and/or peripheral arterial disease

Study & Design

• Study Type: Interventional
• Study Design: Not specified