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Dried Plums for Bone Health in Older Postmenopausal Women

Not Applicable
Completed
Conditions
Bone Diseases, Metabolic
Registration Number
NCT02325895
Lead Sponsor
San Diego State University
Brief Summary

The objective of the investigators current study was to examine whether 50 g dried plum would be as effective as 100 g dried plum in reversing bone loss in osteopenic older postmenopausal women.

Detailed Description

Forty-five randomly assigned into one of three treatment groups: 1) 50g dried plum; 2) 100g dried plum; and 3) control (0g dried plum). All groups received 500mg calcium and 400 IU vitamin D as a daily supplement. Blood samples were collected at baseline, 3 and 6 months to assess biomarkers of bone turnover. Physical activity recall and 3-day food records were obtained at baseline, 3 and 6 months to examine physical activity and dietary confounders as potential covariates

Recruitment & Eligibility

Status
COMPLETED
Sex
Female
Target Recruitment
48
Inclusion Criteria
  • BMD t-score of L1-L4 between -1 to -2.5 standard deviation of the mean
  • Age 65 to 79
Exclusion Criteria
  • BMD t-score at any site fell below 2.5 standard deviation of the mean
  • Subjects treated with calcitonin, bisphosphonates, raloxifene and/or anabolic agents such as parathyroid hormone and growth hormone, or steroids within three months before the start of the study
  • Metabolic bone disease, renal disease, cancer, CVD, diabetes mellitus, respiratory disease, gastrointestinal disease, liver disease or other chronic diseases, heavy smoking (more than twenty cigarettes/day) and current use of any prescription medications known to alter bone and calcium metabolism
  • Regularly consumed dried plum or prune juice were not included in the study.

Study & Design

Study Type
INTERVENTIONAL
Study Design
FACTORIAL
Primary Outcome Measures
NameTimeMethod
Bone Mineral Density6 months
Secondary Outcome Measures
NameTimeMethod
Changes from baseline in bone specific alkaline phosphatase at 3 months and 6 monthsbaseline, 3 months and 6 months

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