Effect of Dried Plum on Bone and Bone Biomarkers in Older Women
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 48
- 主要终点
- Bone Mineral Density
研究概览
简要总结
The objective of the investigators current study was to examine whether 50 g dried plum would be as effective as 100 g dried plum in reversing bone loss in osteopenic older postmenopausal women.
详细描述
Forty-five randomly assigned into one of three treatment groups: 1) 50g dried plum; 2) 100g dried plum; and 3) control (0g dried plum). All groups received 500mg calcium and 400 IU vitamin D as a daily supplement. Blood samples were collected at baseline, 3 and 6 months to assess biomarkers of bone turnover. Physical activity recall and 3-day food records were obtained at baseline, 3 and 6 months to examine physical activity and dietary confounders as potential covariates
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Factorial
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 65 Years 至 79 Years（Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •BMD t-score of L1-L4 between -1 to -2.5 standard deviation of the mean
- •Age 65 to 79
排除标准
- •BMD t-score at any site fell below 2.5 standard deviation of the mean
- •Subjects treated with calcitonin, bisphosphonates, raloxifene and/or anabolic agents such as parathyroid hormone and growth hormone, or steroids within three months before the start of the study
- •Metabolic bone disease, renal disease, cancer, CVD, diabetes mellitus, respiratory disease, gastrointestinal disease, liver disease or other chronic diseases, heavy smoking (more than twenty cigarettes/day) and current use of any prescription medications known to alter bone and calcium metabolism
- •Regularly consumed dried plum or prune juice were not included in the study.
结局指标
主要结局
Bone Mineral Density
时间窗: 6 months
次要结局
- Changes from baseline in bone specific alkaline phosphatase at 3 months and 6 months(baseline, 3 months and 6 months)
研究者
Dr. Shirin Hooshmand
Assistant Professor
San Diego State University