Safety and Efficacy Comparison of Minocycline Microgranules Versus Lymecycline in the Treatment of Mild to Moderate Acne
- Registration Number
- NCT00988026
- Lead Sponsor
- Darier
- Brief Summary
This is a clinical trial to compare the benefits and possible adverse events of two antibiotic treatments for mild to moderate acne. It is expected that minocycline microgranules will be more effective than lymecycline with a better adverse events profile.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 168
Inclusion Criteria
- Both gender
- 14 to 30 years old
- Mild to moderate acne
- Face localization
- At least 20 non-inflammatory lesions OR
- At least 15 inflammatory lesions OR
- At least 30 total lesions AND
- Less than 5 nodular lesions
Exclusion Criteria
- Patients younger than 14 or older than 30 years old
- Less than 20 non-inflammatory lesions OR
- Less than 15 inflammatory lesions OR
- Less than 30 total lesions
- Patients with severe acne
- More than 5 nodular lesions OR
- More than 50 inflammatory lesions OR
- More than 125 total lesions
- Pregnant women
- Lactating women
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Minocycline 100 mg Minocycline vs Lymecycline Minocycline Lymecycline 300 mg Minocycline vs Lymecycline Group B: Lymecycline
- Primary Outcome Measures
Name Time Method Number of inflammatory and non-inflammatory acne lesions 8 weeks
- Secondary Outcome Measures
Name Time Method Incidence of local and systemic adverse events 8 weeks
Trial Locations
- Locations (1)
Servicio de Dermatología. Hospital " Dr. José Eleuterio González" de la Universidad Autónoma de Nuevo León
🇲🇽Monterrey, Nuevo León, Mexico