The Effect of Parenteral Nutrition Supplement Versus Enteral Nutrition Alone on Nutrition Status After Esophagectomy: A Prospective Randomized Controlled Trial
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Esophagus Cancer
- Sponsor
- Shanghai Zhongshan Hospital
- Enrollment
- 95
- Locations
- 1
- Primary Endpoint
- postoperative laboratory parameters changes for nutrition assessment compared to preoperation
- Status
- Completed
- Last Updated
- 12 years ago
Overview
Brief Summary
Malnutrition is common in esophagus cancer patients, especially after surgery therapy. Whether parenteral supplement with enteral nutrtion is benificial for patients after esophagectomy is controversial, when compared with enteral nutrition alone. In this study, the investigators are to examine the effect of enteral nutrition supplemented with parenteral nutrtion on nutrition status after esophagectomy.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Clinical diagnosis of esophagus cancer
- •Undergo esophagectomy
- •Nasoenteral tube is placed or surgical jejunostomy is performed
Exclusion Criteria
- •Contraindication for enteral nutrition or parenteral nutrition
- •Malnutrition before surgery ( BMI \> 30 or \< 18.5)
- •Hepatic dysfunction preoperatively
- •Renal dysfunction preoperatively
- •Infection before surgery
- •Usage of corticosteroid before surgery
Outcomes
Primary Outcomes
postoperative laboratory parameters changes for nutrition assessment compared to preoperation
Time Frame: from one day before surgery to the 7th postoperative day
plasma albumin, prealbumin, transferrin, retinaldehyde-binding protein, total lymphocytes counts
postoperative body composition change compared to preoperation measurement
Time Frame: from one day before surgery to the 7th postoperative day
postoperative body composition is compared to preoperation, bioelectrical impedance spectroscopy is used for measurement of body composition