The Effect of Parenteral Nutrition Supplement Versus Enteral Nutrition Alone on Nutrition Status After Esophagectomy: A Prospective Randomized Controlled Trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 95
- 试验地点
- 1
- 主要终点
- postoperative laboratory parameters changes for nutrition assessment compared to preoperation
研究概览
简要总结
Malnutrition is common in esophagus cancer patients, especially after surgery therapy. Whether parenteral supplement with enteral nutrtion is benificial for patients after esophagectomy is controversial, when compared with enteral nutrition alone. In this study, the investigators are to examine the effect of enteral nutrition supplemented with parenteral nutrtion on nutrition status after esophagectomy.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Clinical diagnosis of esophagus cancer
- •Undergo esophagectomy
- •Nasoenteral tube is placed or surgical jejunostomy is performed
排除标准
- •Contraindication for enteral nutrition or parenteral nutrition
- •Malnutrition before surgery ( BMI > 30 or < 18.5)
- •Hepatic dysfunction preoperatively
- •Renal dysfunction preoperatively
- •Infection before surgery
- •Usage of corticosteroid before surgery
结局指标
主要结局
postoperative laboratory parameters changes for nutrition assessment compared to preoperation
时间窗: from one day before surgery to the 7th postoperative day
plasma albumin, prealbumin, transferrin, retinaldehyde-binding protein, total lymphocytes counts
postoperative body composition change compared to preoperation measurement
时间窗: from one day before surgery to the 7th postoperative day
postoperative body composition is compared to preoperation, bioelectrical impedance spectroscopy is used for measurement of body composition
次要结局
未报告次要终点