Troponin Activator to Restore Diaphragm Function in COPD
Completed
- Conditions
- diaphragm weakness in COPD1002830210038716
- Registration Number
- NL-OMON40872
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 26
Inclusion Criteria
-Patients with COPD scheduled for a thoracotomy for resection of a small pulmonary tumor.
-Patients with normal lung function scheduled for a thoracotomy for resection of a small pulmonary tumor. (These patients will serve as controls).
-Age: >18 years
-Gender: both male and female
-all ethnic backgrounds
Exclusion Criteria
-CHF (NYHA class III-IV)
-Neuromuscular disease
-Drugs known to alter muscle structure and function
-Chronic metabolic disease
-Pulmonary hypertension
-Chronic use of corticosteroids (defined as >7.5 mg/day for at least 3 months)
->10% weight loss within last 6 months.
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>* contractile force of single diaphragm muscle fibers</p><br>
- Secondary Outcome Measures
Name Time Method <p>* contractile force of single latissimus dorsi muscle fibers</p><br>