SEP Changes During Deep Anesthesia

Not Applicable

• Conditions: Somatosensory Evoked Potentials, and Electroencephalography
• Interventions: Drug: Propofol

• Registration Number: NCT02394002
• Lead Sponsor: Andrea Szelenyi

Brief Summary

The relation between burst and suppression periods in transcranial and direct cortical recorded EEG with cortical amplitudes median nerve somatosensory evoked potentials is studied.

60 patients are included in this study: 15 patients undergoing brain tumor surgery, 15 spine surgery (University Hospital Düsseldorf) and 30 patients during general surgical procedures (Helios Klinikum Wuppertal).

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Status Verified: 2015-03
• Study Start: 2015-03
• Study First Submitted: 2015-03-16
• Study First Submitted QC: 2015-03-19
• Last Update Submitted: 2015-03-19
• Study First Posted: 2015-03-20
• Last Update Posted: 2015-03-20
• Primary Completion: 2016-03
• Study Completion: 2017-03

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• Location Helios Klinikum Wuppertal: neurological healthy patients, which undergo an elective surgery under general anaesthesia
• Location Department of Neurosurgery, University Hospital Düsseldorf: all patients with intracranial interventions and the possibility to place a stripe electrode without complications on cortex (it is decided by the surgeon while surgery because of the situs and tumorlocation)

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Exclusion Criteria

• periodical consumption of drugs and pharmaceuticals which influence cortical excitability
• intraoperative contraindication for required depth of anaesthesia
• neurological pre-existing illness
• advanced hepatic insufficiency

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Brain surgery	Propofol	Somatosensory evoked potentials in relation to anasthesia (Propofol bolus) induced burst and suppression periods in electroencephalography
General surgery	Propofol	Somatosensory evoked potentials in relation to anasthesia (Propofol bolus) induced burst and suppression periods in electroencephalography
Spine surgery	Propofol	Somatosensory evoked potentials in relation to anasthesia (Propofol bolus) induced burst and suppression periods in electroencephalography

Primary Outcome Measures

Name	Time	Method
SEP ampiltude in burst-suppression-EEG	2 hours

Trial Locations

Locations (1)

Neurosurgical Clinic; 🇩🇪 Duesseldorf, Germany