Specific Versus General Cognitive Remediation for Schizophrenia
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Schizophrenia
- Sponsor
- Hôpital le Vinatier
- Enrollment
- 151
- Primary Endpoint
- Change from baseline in executive functioning at week 12
- Status
- Completed
- Last Updated
- 10 years ago
Overview
Brief Summary
Rationale:
Cognitive deficits are a core feature in schizophrenia. Conventional treatments (antipsychotic medication and psychological treatments) have limited effects so cognitive remediation programs were designed to alleviate the problems. Interventions typically involve a variety of exercises in a paper and pencil or a computerized format with a growing number of specialized computer programs now being developed. However, many of these programs lack specificity which does not allow an individual's specific needs to be addressed. More targeted interventions might increase the effects of therapy so RECOS - COgnitive REmediation for Schizophrenia - was developed to fit this gap.
Methods: This is a multicenter, randomized, controlled study comparing patients aged 18 to 45 years suffering from schizophrenia according to DSM-IV-TR. RECOS will be compared to an already validated program (CRT).
220 patients will be randomized as follows :
- Arm 1 : RECOS (42 h)
- Arm 2 : CRT (42 h) The recruitment is performed by psychiatrists in Lyon, Paris, Clermont-de-l'Oise, Niort, Bordeaux, Ville-Evrard and Lausanne.
Investigators
Nicolas FRANCK, Pr
Professor (Claude Bernard University), head of department (Hôpital le Vinatier), principal investigator
Hôpital le Vinatier
Eligibility Criteria
Inclusion Criteria
- •men and women aged 18 to 45 years
- •French speaker or French schooling since 7 years
- •clinical stability
- •diagnosis of schizophrenia
Exclusion Criteria
- •visual or auditory disorder
- •history of neurological illness or trauma
- •alcohol or drug dependence
- •mental retardation
Outcomes
Primary Outcomes
Change from baseline in executive functioning at week 12
Time Frame: week 12
BADS(Behavioral Assessement of Dysexecutive Functions) total score
Secondary Outcomes
- Change from baseline in executive functioning, attention, memory and visuospatial abilities at week 12(week 12)
- Change from baseline in insight at week 12(week 12)
- Change from baseline in symptoms at week 12(week 12)
- Change from baseline in self-esteem at week 12(week 12)