Feasibility of aspiration of Ultrasound guided Synovial fluid from Inflamed Small hand joints.

Recruiting

• Conditions: osteoarthritis; 10023213

• Registration Number: NL-OMON53105
• Lead Sponsor: eids Universitair Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 11 June 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 20

Inclusion Criteria

1. Diagnoses of hand OA, rheumatoid arthritis, or psoriatic arthritis according
to recognised classification criteria sets
2. Presence of an inflamed interphalangeal or MCP joint for which the treating
rheumatologist has proposed treatment with an intra-articular injection with
corticosteroids.
3. Patients should be 40 years of age or older.

Exclusion Criteria

1. Patients that had an intra-articular injection with corticosteroids, an
operation or an important trauma in the same joint less than 12 weeks before
the intended injection
2. The presence of a chronic inflammatory disease (other than OA, rheumatoid
arthritis or psoriatic arthritis), such as poly-articular gout
3. Contra-indication for an intra-articular injection such as anti-coagulant
(vitamin K antagonist) use that can*t be discontinued.

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>• The percentage of study joints in which a successful aspiration is performed.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>• The volume of the obtained synovial fluid collections (µl).<br /><br>• To analyse the presence of cytokines (such as IL-1, IL-6, IL-8, TNF-a), of<br /><br>immune cells (neutrophils, macrophages, lymphocytes) and adipokines and lipid<br /><br>mediators in the synovial fluid.<br /><br>• The relation between the US effusion score and volume of synovial fluid that<br /><br>is aspirated from the study joint.<br /><br><br /><br>Other study parameters<br /><br>• Association of physical and ultrasound inflammatory/structural features and<br /><br>the ability to obtain synovial fluid (i.e. obesity, big structural<br /><br>abnormalities, such as osteophytes or joint space narrowing)<br /><br>• To investigate whether there is a difference in feasibility, amount of<br /><br>synovial fluid and analyses between hand OA and inflammatory arthritis<br /><br>(rheumatoid arthritis and psoriatic arthritis) </p><br>