To Study the role of vitamin D in asthma

Not Applicable

Conditions: Health Condition 1: J454- Moderate persistent asthma

Registration Number: CTRI/2022/11/047299

Lead Sponsor: Maulana azad medical college and associated Lok Nayak Hospital

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: ot Yet Recruiting

Sex: Not specified

Target Recruitment: 0

Inclusion Criteria

Patients with moderate asthma diagnosed according to latest GINA guidelines [2022] for at least 1 month

Exclusion Criteria

1.History of any chronic disease other than asthma (like cancer, liver disease, gall bladder disease, diabetes, uncontrolled hypertension and GI disorders affecting vitamin D absorption).

2.Respiratory tract infection within past 4 weeks.

3.Known allergy to vitamin D or taking vitamin D supplements.

4.Hypercalcemia ( >11mg/dl) or taking calcium supplements or history of recurrent kidney stones, Hyperparathyroidism ( >65pg/ml) and deranged serum electrolytes.

5.Use of concomitant medications that alter vitamin D metabolism (e.g phenytoin, corticosteroids) or absorption (e.g cholestyramine) or those that interfere with study endpoints.

6.History of cigarette smoking (more than 10 packs a year).

7.Deranged LFT (Liver enzymes >3 times upper limit of normal) or KFT (serum creatinine >1.2mg/dl)

8.Pregnant and nursing mothers

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1)Asthma control test scores (ACT). <br/ ><br>2)Frequency of asthma exacerbation. <br/ ><br>Timepoint: 0, 6weeks, 12weeks, 18weeks, 20weeks <br/ ><br>

Secondary Outcome Measures

Name	Time	Method
1)Predictive percentage of forced expiratory volume in 1st second (FeV1), FEV1/FVC. <br/ ><br>2)Serum eosinophils levels. <br/ ><br>3)Quality of life (AQLQ- Asthma quality of life questionnaire). <br/ ><br>4)Percentage of patients requiring change in asthma treatment (step up / step down). <br/ ><br>5)No. of emergency visits and hospitalizations for asthma. <br/ ><br>6)Adverse events. <br/ ><br>Timepoint: 0, 6weeks, 12weeks, 18weeks, 20weeks