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Clinical Trials/NCT06350175
NCT06350175
Withdrawn
Phase 4

Emergency Department Based Management of Tobacco Use Disorder

West Virginia University0 sites100 target enrollmentAugust 2024

Overview

Phase
Phase 4
Intervention
Not specified
Conditions
Tobacco Use Disorder
Sponsor
West Virginia University
Enrollment
100
Primary Endpoint
Heaviness of Smoking Index (Baseline)
Status
Withdrawn
Last Updated
last year

Overview

Brief Summary

The objective of this study is to determine the effectiveness of ED initiated NRT on tobacco cessation point abstinence rates as reported by patients at 2 weeks and 1 month post randomization, and continued abstinence rates at 3 months compared to standard of care therapy.

Registry
clinicaltrials.gov
Start Date
August 2024
End Date
June 2025
Last Updated
last year
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Responsible Party
Principal Investigator
Principal Investigator

Bradley End

Assistant Professor

West Virginia University

Eligibility Criteria

Inclusion Criteria

  • Current daily use cigarettes greater than or equal to ½ pack per day
  • Stable for discharge from the ED
  • Able and willing to complete telephone/electronic follow up at scheduled intervals
  • Reported English speaking

Exclusion Criteria

  • Patients enrolled in specific health insurance plans (PEIA, The Health Plan or Medicaid medical insurance)
  • WVU students
  • Medically unstable patients
  • Patients with clinical decompensation or who are admitted to the hospital
  • Patients who are discharged to residential treatment facilities for detoxification
  • Uncontrolled psychiatric disorder or psychiatric emergency
  • Individuals who are unable to provide consent
  • Incarcerated individuals
  • Language barrier
  • Currently pregnant or attempting to become pregnant

Outcomes

Primary Outcomes

Heaviness of Smoking Index (Baseline)

Time Frame: Baseline

A validated measure used to determine the level of nicotine addiction, with a scale of 0-6 (3 indicates moderate addiction, \>5 is severe)

Percentage of Continued Abstinence Rate (1 month)

Time Frame: 1 Month post initial dose

Percentage of subjects who self-report continued abstinence in tobacco use at 1 month from initial dose given during the ED visit.

Patient Health Questionnaire 2 (Baseline)

Time Frame: Baseline

A validated instrument to assess the frequency of depression and anhedonia screen for depression, scores can range from 0 to 6, with each item scored from 0 (not at all) to 3 (nearly every day). Scores greater than or equal to typically indicate depression.

Percentage of Continued Abstinence Rate (2 weeks)

Time Frame: 2 Weeks post initial dose

Percentage of subjects who self-report continued abstinence in tobacco use at 2 weeks from initial dose given during the ED visit.

Percentage of Continued Abstinence Rate (3 months)

Time Frame: 3 Months post initial dose

Percentage of subjects who self-report continued abstinence in tobacco use at 3 months from initial dose given during the ED visit.

Heaviness of Smoking Index (3 months from baseline)

Time Frame: 3 months from baseline

A validated measure used to determine the level of nicotine addiction, with a scale of 0-6 (3 indicates moderate addiction, \>5 is severe)

Richmond Test (3 months from baseline)

Time Frame: 3 months from baseline

A validated instrument to assess motivation to quit smoking. This is scored on a 0-10 scale with 5-6 indicating moderate motivation to quit and 7+ indicating strong motivation to quit.

Patient Health Questionnaire 2 (3 months from baseline)

Time Frame: 3 months from baseline

A validated instrument to assess the frequency of depression and anhedonia screen for depression, scores can range from 0 to 6, with each item scored from 0 (not at all) to 3 (nearly every day). Scores greater than or equal to typically indicate depression.

Richmond Test (Baseline)

Time Frame: Baseline

A validated instrument to assess motivation to quit smoking. This is scored on a 0-10 scale with 5-6 indicating moderate motivation to quit and 7+ indicating strong motivation to quit.

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