A Prospective Study on The"Management of Hypertension in Young and Middle-aged Subjects in Enterprises Setting"

Suspended

• Conditions: Hypertension; Blood Pressure

• Registration Number: NCT04135911
• Lead Sponsor: Yan Li

Brief Summary

In recent years, with the investment from government in the health management of the elderly, community management of hypertension in the elderly has made great progress in management rate and standardized management, but the management of young and middle-aged patients with hypertension is still blank.

Workplace pressure measurement may be more suitable for most of the young and middle-aged patients to find high blood pressure and monitor blood pressure changes in time.

However, there is not much research on workplace pressure measurement. Whether blood pressure measurement in the workplace can reduce the white coat effect, and how it relates to home blood pressure and ambulatory blood pressure is still unclear.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2019-10-21
• Study First Submitted QC: 2019-10-21
• Study First Posted: 2019-10-23
• Study Start: 2019-12-30
• Status Verified: 2025-01
• Last Update Submitted: 2025-01-07
• Last Update Posted: 2025-01-09
• Primary Completion: 2026-03-31
• Study Completion: 2026-03-31

Recruitment & Eligibility

• Status: SUSPENDED
• Sex: All
• Target Recruitment: 2000

Inclusion Criteria

1. Male and female sex, aged 18-65 years
2. Three different daytime workplace blood pressure measurements meet the limits: systolic blood pressure ≥ 120 mmHg, or diastolic blood pressure ≥80 mmHg
3. Hypertensive patients who are taking antihypertensive drugs
4. Willing to provide information about disease history and lifestyle
5. Willing to receive follow-up for up to 2-3 years
6. Sign the informed consent

Exclusion Criteria

1. Having the onset of cardiovascular and cerebrovascular diseases such as stroke, myocardial infarction or heart failure within 6 months
2. Having a history of atrial fibrillation or frequent arrhythmia
3. Complicating other diseases that are not suitable for the trial, such as thyroid disease with active medication, acute infectious diseases, chronic mental illness, and tumors
4. The subject is participating in other clinical studies.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Diagnostic classification in hypertension	2 years	Differences in diagnostic classification between workplace blood pressure and daytime ambulatory blood pressure in the classification of hypertension (masked hypertension or white coat hypertension)

Secondary Outcome Measures

Name	Time	Method
Change in different blood pressure measurement	2 years	Differences in workplace blood pressure, daytime ambulatory blood pressure, home blood pressure and 24-hour ambulatory blood pressure
The distribution of heart rate in young and middle-aged subjects	2 years	The distribution of heart rate in young and middle-aged subjects who were diagnosed with hypertension
Progression of target organ damage	2 years	Differences in the progression of target organ damage between controlled or uncontrolled subjects or between subjects with fast and slow heart rate
The development of with-coat hypertension	2 years	The development of white-coat hypertension as persistent hypertension and other types of hypertension or normal blood pressure and changes in target organ damage
The proportion of masked hypertension in patients with normal high blood pressure	2 years	The proportion of masked hypertension in patients with normal high blood pressure and the change in outcome after treatment intervention and changes in target organ damage

Trial Locations

Locations (1)

Ruijin Hospital; 🇨🇳 Shanghai, Shanghai, China