Correlation between the Clinicopathological Spectrum of Abnormal uterinebleeding and Different methods of endometrial sampling in a Tertiary care unit

Abnormal Uterine Bleeding is the most common presenting complaint among women of

all age group visiting Gynecology . One third of patients attending gynaecology OPD

present with complaints of abnormal uterine bleeding(1). AUB is charecterised by any

deviation form the normal pattern/frequency, duration and severity of normal menstrual

flow.Recently, the International Federation of Gynecology and Obstetrics

working group on menstrual disorder has developed a

classification system (PALM-COEIN) for causes of the

AUB in non-gravid women of reproductive age. There

are nine main categories, which are arranged according

to the acronym PALM-COEIN: Polyp; adenomyosis;

leiomyoma; malignancy and hyperplasia; coagulopathy;

ovulatory dysfunction; endometritis; iatrogenic; and not

yet classified [2].Although radiological examination is the first mode of diagnosis in most

cases, Histopathological evaluation is the most relied method for diagnosis and planning

further management.The various mode of obtaining Endometrial samples like – D and C,

Endocell, Mannual vaccum aspiration have made the diagnosis of AUB much easier.

Endometrial biopsy and curettage are chief sampling methods [3].The cause of AUB may

widely vary from a simple polyp to malignancy. AUB in perimenopausal and

postmenopausal patients warrants thorough evaluation because AUB is the only clinical

symptom of endometrial carcinoma in most patients.