Assessing the diagnostic value of non-invasive coronary flow reserve measurement
- Conditions
- coronary microvascular dysfunction (CMD)Coronary microvascular dysfunction (microvascular angina pectoris)
- Registration Number
- NL-OMON42618
- Lead Sponsor
- niversitair Medisch Centrum Sint Radboud
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Withdrawn
- Sex
- Not specified
- Target Recruitment
- 60
Patients with stable angina will be eligible if their clinically indicated coronary angiogram included a fractional flow reserve (FFR) measurement in the left anterior descending (LAD) artery. Since coronary flow reserve (CFR) is automatically measured together with FFR, invasive CFR measurements are clinically available in these patients.
- Significant coronary stenosis (FFR < 0.8) and/or placement a coronary stent in the LAD after FFR/CFR measurement during the CAG
- History of coronary artery bypass grafts (CABG)
- Unstable angina
- Any contra-indication to provocative stress testing with adenosine
These include:Previous adverse reaction to adenosine, atrial-ventricular blockage (2nd en 3rd degree) and no pacemaker, long QT syndrome, Astma and COPD Gold III or IV
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>1) To appraise the agreement between non-invasive CFR measurements using<br /><br>echocardiography (TTDE) and invasively measured CFR.<br /><br>2) To evaluate the feasibility of a CFR measurement using TTDE.<br /><br>3) To assess the intra-operator variability of TTDE</p><br>
- Secondary Outcome Measures
Name Time Method <p>not applicable</p><br>