Effectiveness Study of Cognitive Behavioral Therapy for Depression - an open-label pilot study - Cognitive Behavioral Therapy for Depression - an open-label pilot study

A total of 27 patients with major depression were enrolled and 26 (96%) completed the study. The mean total score of Beck Depression Inventory-II (BDI-II) for all patients (Intention-to-treat sample:ITT) improved from 32.6 to 11.7 during the program with the mean change of 20.8 (95% confidence interval: 17.0 to 24.8). Within-group effect size at endpoint assessment was 2.64 (Cohen's d) on the BDI-II. For the ITT sample, 21 (77.7%) patients showed treatment response and 17 patients (63.0%) achieved remission and at the end of the program. Significant improvement in measurement of objective depression severity, global improvement, dysfunctional attitude, global functioning and subjective well-being were also observed (all p values<0.001).