Metabolic Phenotypes in Childhood Obesity

Completed

• Conditions: Obesity, Pediatric
• Interventions: Other: Blood sampling

• Registration Number: NCT03014856
• Lead Sponsor: Hasselt University

Brief Summary

This study provides a sound basis towards a better understanding of the biochemical mechanisms behind childhood obesity and its metabolic phenotypes, which will be of great importance towards the development of more personalized prevention and treatment in future.

Detailed Description

The aim of this study was to identify the plasma metabolic profile associated with childhood obesity and its phenotypes..

This cross-sectional study was set-up to examine the metabolic profile in fasting plasma samples from 65 overweight and obese (OB) children and 37 normal-weight (NW) controls aged 8 to 18 years. The obtained plasma 1H-NMR spectra were rationally divided into 110 integration regions, representing the metabolic phenotype. These integration regions reflect the relative metabolite concentrations and were used as statistical variables to construct a classification model in discriminating between OB and NW children and adolescents. In addition, two metabolic phenotypes were defined within the OB group, i.e. the metabolically "healthy" obese (MHO) and metabolically unhealthy obese (MUO) phenotype which are both classified as obese but with respectively, none (MHO) or at least two components (MUO) of the metabolic syndrome.

Study Timeline

• Study Start: 2012-05
• Primary Completion: 2013-12
• Study Completion: 2014-12
• Study First Submitted: 2016-12-13
• Status Verified: 2017-01
• Study First Submitted QC: 2017-01-05
• Last Update Submitted: 2017-01-05
• Study First Posted: 2017-01-09
• Last Update Posted: 2017-01-09

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 102

Inclusion Criteria

• aged 8 to 18
• normal-weight, overweight or obese according to the International Obesity Task Force (IOTF) Body Mass Index (BMI) criteria
• fasted for at least 8 hours

Exclusion Criteria

• Subjects taking any medication or having serious chronic or acute illness within two weeks preceding the clinical examination,

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
OB-NMR	Blood sampling	overweight and obese children and adolescents
NMR-C	Blood sampling	normal-weight children and adolescents

Primary Outcome Measures

Name	Time	Method
metabolic phenotype of childhood obesity	day 1	Significant metabolic changes in blood plasma of obese children and adolescents and normal-weight control subjects

Secondary Outcome Measures

Name	Time	Method
metabolic phenotype of metabolically healthy and unhealthy obese children and adolescents	day 1	Significant metabolic changes in blood plasma of metabolically healthy obese and metabolically unhealthy obese children and adolescents