The effect of ethanol on intestinal permeability and integrity in healthy individuals
- Conditions
- increased permeabiliyleaky gut syndrome10017977
- Registration Number
- NL-OMON33245
- Lead Sponsor
- niversiteit Maastricht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 17
- Signed informed consent
- Male gender
- Age between 18 and 45 years
- Normal medical history and physical examination
- Normal liver function tests
- Caucausian ethnicity
- BMI between 18 and 30
- History of gastrointestinal disorders or abdominal surgery (uncomplicated appendectomy and cholecystectomy allowed, other surgery upon judgement of the principal investigator)
- History of alcohol abuse or current excessive alcolhol consumption (>2 alcoholic beverages per day or >14 alcoholic beverages per week)
- Recent or chronic medications that may interact with ethanol metabolism or intestinal permeability
- Smoking
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The primary outcome is to assess the small intestinal permeability by means of<br /><br>sugar permeability testing after intraduodenal administration of ethanol.</p><br>
- Secondary Outcome Measures
Name Time Method <p>The secondary outcomes are assessing tight junctions structure in the biopsy<br /><br>specimens, measuring serum and mucosal ethanol and acetaldehyde concentrations.<br /><br>Ex vivo determination of the effect of ethanol and acetaldehyde on tight<br /><br>junction functionality using Ussing chambers</p><br>
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