The Impact of Inflammatory Adhesion on the Prognosis of Colon Cancer Patients

Completed

• Conditions: Colon Cancer

• Registration Number: NCT06655285
• Lead Sponsor: Cancer Institute and Hospital, Chinese Academy of Medical Sciences

Brief Summary

The purpose of this study is to explore the impact of tumor-associated inflammatory adhesion on the prognosis of colon cancer patients.

Detailed Description

In some colon cancer patients, although adhesions between the tumor tissue and surrounding organs are found during surgery, postoperative pathology confirms that the tumor has not directly invaded the adhered organs; instead, the adhesions are caused by tumor-associated inflammation. This condition is defined as tumor-associated inflammatory adhesion.

Currently, the impact of tumor-associated inflammatory adhesion on patient prognosis is still unclear. This study aims to explore the impact of tumor-associated inflammatory adhesion on the prognosis of colon cancer patients through the Surveillance, Epidemiology, and End Results (SEER) and Chinese multi-center databases.

Study Timeline

• Study First Submitted: 2024-10-22
• Study First Submitted QC: 2024-10-22
• Study First Posted: 2024-10-23
• Study Start: 2024-10-24
• Primary Completion: 2024-10-26
• Study Completion: 2024-10-27
• Status Verified: 2024-11
• Last Update Submitted: 2024-11-06
• Last Update Posted: 2024-11-07

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 229

Inclusion Criteria

1. The patient was pathologically diagnosed as colon adenocarcinoma by endoscopic biopsy before operation.
2. All patients were considered to have tumors invading adjacent organs during surgery
3. All patients underwent radical surgery.

Exclusion Criteria

1. Patients with distant metastasis, recurrent colon cancer and pT4b CRC were excluded.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Overall survival time (OS)	up to 10 years	OS, defined as the time from the first diagnosis to death from any cause or the last follow-up for surviving patients
Cancer-specific survival time (CSS)	up to 10 years	CSS refers to the duration from diagnosis of a tumor until the patient succumbs to the tumor, excluding deaths from other causes.
Recurrence free survival time (RFS)	up to 10 years	RFS is the time from the time a patient achieved R0 resection after surgery to the time of recurrence or the end of follow-up.

Trial Locations

Locations (1)

Cancer Hospital Chinese Academy of Medical Sciences; 🇨🇳 Beijing, Beijing, China