Preimplantation genetic screening (PGS) in women of advanced maternal age
Completed
- Conditions
- Preimplantation genetic screeningPregnancy and Childbirth
- Registration Number
- ISRCTN38014610
- Lead Sponsor
- Serono Nordic AB (Sweden)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 320
Inclusion Criteria
1. Couples with infertility of female or male origin
2. Intending to undergo IVF or intracytoplasmic sperm injection (ICSI)
3. Signed a written consent form
4. The age of the woman was over 38 years
5. The couple had to have at least three embryos of good morphological quality (GQE). After an amendment, owing to introduction of SET in Sweden in 2003, only two GQE were required.
Randomisation, using a data program, was performed on day three.
Exclusion Criteria
Previous enrolment.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Clinical pregnancy rate, shown as foetal heart activity per randomised patient, measured six to seven weeks after the transfer of the embryo(s).
- Secondary Outcome Measures
Name Time Method 1. Pregnancy rate per transfer, measured two weeks after the transfer of the embryo(s)<br>2. Rate of implantation, measured six to seven weeks after the transfer of the embryo(s) <br>3. Spontaneous abortion and delivery, measured by looking at hospital records throughout the nine months after the transfer of the embryo(s)