DARK STUDY "DysbetalipoproteinemiA and atheRoma Risk"

• Conditions: Dysbetalipoproteinemia

• Registration Number: NCT01760265
• Lead Sponsor: Hospices Civils de Lyon

Brief Summary

Dysbetalipoproteinemia (type III, Fredrickson's classification) is a rare metabolic disorder. It results from a defect in the clearance of VLDL and chylomicron remnants due to homozygous APOE2 variants or heterozygous APOE mutations, and there is an elevated plasma cholesterol and triglycerides.

As a consequence of the derangements in lipoprotein metabolism, dysbetalipoproteinemia predispose to the premature development of atherosclerosis.

However among this population there is heterogeneity in development of cardiovascular complications and the determinants remain unclear actually.

The aim of the investigators study is to evaluate the intensity of clinical atherosclerosis, and identify its determinants.

Detailed Description

Not available

Study Timeline

• Status Verified: 2013-01
• Study Start: 2013-01
• Study First Submitted: 2013-01-02
• Study First Submitted QC: 2013-01-03
• Study First Posted: 2013-01-04
• Last Update Submitted: 2013-01-25
• Last Update Posted: 2013-01-28
• Primary Completion: 2013-06
• Study Completion: 2013-06

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• apo E gene sequencing in CBE (Centre de Biologie Est / Hospices Civils de Lyon / France) laboratory in Lyon until December 2012

Exclusion Criteria

• age < 40 years
• refused participation

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Computed tomographic measurements for coronary-artery calcium	Day one : the coronary calcium score is assessed on the date of measurement	Comparison with eventual previous examinations.

Secondary Outcome Measures

Name	Time	Method
Measurement of carotid intima-media by ultrasonography	Day one : on the date of measurement	Comparison with eventual previous examinations.
Measurement of ankle brachial index	Day one : on the date of measurement	Comparison with eventual previous examinations

Trial Locations

Locations (1)

Hospices Civils de Lyon - Groupement Hospitalier Est; 🇫🇷 Bron, France