ong term clinical outcome of treatment for chronic hepatitis C in patients with advanced fibrosis

Recruiting

• Conditions: chronic liver disease; chronic viral hepatitis; 10019654; 10047438; 10019818

• Registration Number: NL-OMON34894
• Lead Sponsor: Erasmus MC, Universitair Medisch Centrum Rotterdam

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 64

Inclusion Criteria

- history of chronic Hepatitis C
- Interferon based antiviral treatment for chronic hepatitis C between 1990 en 2003
- biopsy-proven advanced liver fibrosis (metavir score F3-F4)

Exclusion Criteria

- HIV infection
- chronic hepatitis B infection
- secondary liver disease

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>- hepatcellular carcinoma<br /><br>- liver failure: Ascites/encephalopathy/jaundice/variceal bleed<br /><br>- death<br /><br>- new onset Diabetes Mellitus</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- Biochemical results:<br /><br>ALT/AST/albumin/bilirubin/creatinine/glucose/insulin/HbA1c<br /><br>- Hemological results: platelet count/prothrombin time<br /><br>- Virology: viral load<br /><br>- Ultrasound: spleen size<br /><br>- Fibroscan results: liver stiffness</p><br>