The Role of IL-6 in Exercise-Induced Anorexia in Normal-weight Boys
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 15
- 试验地点
- 2
- 主要终点
- Food Intake
研究概览
简要总结
This study investigates the effect of high intensity exercise, with and without the inflammation inhibitor, ibuprofen, on plasma levels of IL-6 and other selective biomarkers of inflammation and appetite on food intake and subjective ratings of appetite in normal-weight boys.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
盲法说明
Water control and ibuprofen solution contained 0.8 g of Sucralose (Heartland Food Products Group, Amsterdam, HP, Netherlands) and 1.2 g of orange flavored Kool-Aid (Kraft Foods, Northfield, IL, United States) to mask the taste of the Motrin solution. To match sweetness and calorie content of the ibuprofen Motrin drink, the water control also contained 6 mL high fructose corn syrup (ACH Food Companies, Mississauga, ON, Canada).
入排标准
- 年龄范围
- 13 Years 至 18 Years（Child, Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •13-18 yrs, healthy, male
排除标准
- •female, heamatophobia, following a diete, diagnosed with diabetes or other metabolic diseases, scoring ≥11 on an Eating Habit Questionnaire
研究组 & 干预措施
Water and Rest
Water and High Intensity Exercise
干预措施: High Intensity Exercise/Ibuprofen (Other)
Ibuprofen and Rest
干预措施: High Intensity Exercise/Ibuprofen (Other)
Ibuprofen and High Intensity Exercise
干预措施: High Intensity Exercise/Ibuprofen (Other)
结局指标
主要结局
Food Intake
时间窗: 100-120 min
Participants were provided with ad libitum lunch meal, consisting of rice (Uncle Ben's, Bolton, ON, Canada), beef meatballs (President's Choice, Brampton, ON, Canada) and tomato sauce (Ragu, Mount Prospect, IL, USA) at 100 - 120 min. The meatballs were cut into small and uniform pieces and were mixed homogeneously with the other ingredients in a bowl. One bowl was a 479.5 g portion which represented 827.5 kcal, 30.8 g fat, 104.8 g carbohydrate and 30.2 g protein based on the weight consumed and the compositional information provided by the manufacturers. Two portions we served in 10 min intervals and FI from the pizza meal was calculated based on the weight consumed during the lunch. Participants were instructed to eat until comfortably and stay seated during the duration of the meal.
Visual Analog Scale Appetite Scores
时间窗: 0-120min
Visual Analog Scales were employed to assess subjective appetite based on the following questionnaires: Determination to Eat, Hunger, Fullness and Prospective Food Consumption.
Appetite Biomarkers
时间窗: 0-120min
Active Ghrelin, Blood Glucose, Insulin, Peptide-YY and Glucagon-like peptide-1 were determined as appetite biomarkers.
Inflammatory and Stress Biomarkers
时间窗: 0-120min
Interleukin-6, Tumor necrosis factor alpha and cortisol were determined as appetite biomarkers.
次要结局
未报告次要终点
研究者
G. Harvey Anderson
Professor
University of Toronto