Comparison of flow-mediated dilatation with local thermal hyperaemia as a measure of endothelial function.

Recruiting

• Conditions: Bloedvataandoeningen; endotheel dysfunctie; Endothelial dysfunction

• Registration Number: NL-OMON40563
• Lead Sponsor: Erasmus MC, Universitair Medisch Centrum Rotterdam

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 40

Inclusion Criteria

Non-smokers:
- Healthy Men
- Age between 25-65 years
- Non-smoking for > 5 years
- Body mass index between 18 and 30 kg/m2
- Capable and willing to give informed consent
- General good health, based on medical history and physical examination
- Systolic BP measured on day of the experiment should be < 160 mmHg;Smokers:
- As for the non-smokers
- In addition smoking at least on average 14 cigarettes per day for at least 5 years

Exclusion Criteria

- female subjects
- History of cardiovascular disease
- Use of vasoactive drugs
- Drug or/and alcohol abuse

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Degree of correlation between FMD and LTH</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Involvement of NO in LTH response<br /><br>Changes in FMD and LTH in response to beetroot juice consumption</p><br>