Pancreatic Exocrine Insufficiency After Bariatric Surgery
- Conditions
- Obesity, MorbidPancreatic Insufficiency
- Interventions
- Procedure: SleeveGastrectomy
- Registration Number
- NCT03279653
- Lead Sponsor
- Umraniye Education and Research Hospital
- Brief Summary
Main proposed benefit of sleeve gastrectomy is loss of ghrelin secreting tissue. Some studies express that ghrelin augment pancreatic regeneration. Therefore we hypothesized that with sleeve gastrectomy it may result with pancreatic insufficiency.
- Detailed Description
Mechanism of weight loss differs in bariatric surgery according to type of surgery.
With sleeve gastrectomy which has restrictive mechanism, ghrelin excretion decreases, and this condition is attributed as an additional mechanism in weight loss.
Ghrelin effects pancreatic regeneration, and loss of ghrelin may result with pancreatic insufficiency. Therefore we aimed to deteremine this association.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 50
Patients underwent bariatric surgery (Sleeve gastrectomy) after concordonce with NIH criteria
Additional operations to sleeve gastrectomy like duodenal switch. Other bariatric operations.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description SleeveGastrectomy SleeveGastrectomy Sleeve Gastrectomy will be performed. Preoperative and Postoperative pancreatic enzyme sufficiency (with steatocrit or fecal elastase) will be compared.
- Primary Outcome Measures
Name Time Method Pancreatic excorine enzyme difference post operative 3 months Effect of operation on pancreatic excorine enzyme
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Umraniye Education and Research Hospital
🇹🇷Istanbul, Ümraniye, Turkey